Abstract LB-254: High-throughput drug matrix screen with SMAC (second mitochondria-derived activator of caspases)-mimetic birinapant in high-grade serous ovarian cancer cell lines identifies synergism

• Published in: Cancer research (Chicago, Ill.) Vol. 75; no. 15_Supplement; p. LB-254
• Main Authors: Bunch, Kristen, Goldlust, Ian, Thomas, Craig, Hernandez, Lidia, Guha, Rajarshi, Annunziata, Christina
• Format: Journal Article
• Language: English
• Published: 01.08.2015

Background: Inhibitors of apoptosis (IAPs) are attractive anti-cancer therapeutic targets as a mechanism to sensitize cancer cells to apoptosis. IAPs are overexpressed in ovarian cancer and portend a poor prognosis. SMAC- mimetics are IAP antagonists that have shown in vitro and in vivo antitumor ac...