Abstract 899: High fat diet induced DNA methylation at transcription factor binding region and repressed gene expression of a metastasis suppressor E-cadherin in primary site of murine metastatic breast cancer (MBC), and promoted invasion of MBC cells to lung and liver

• Published in: Cancer research (Chicago, Ill.) Vol. 75; no. 15_Supplement; p. 899
• Main Authors: Zhang, Yukun, Wang, Wendan, Yang, Xujuan, Helferich, William G.
• Format: Journal Article
• Language: English
• Published: 01.08.2015
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2015-899

Breast cancer (BC) is the most prevalent type of cancer among women in the US. BC survival rate has long been compromised by metastasis. Consumption of a high fat diet (HFD) is associated with increased BC risk. However, the underlying molecular mechanisms remain inconclusive. E-cadherin (Cdh1) is a...