Abstract 2518: Effective vaccination against melanoma in an animal study: Combination of laser-assisted dermal skin delivery and cross-presenting XCR1+ dermal DCs targeting

• Published in: Cancer research (Chicago, Ill.) Vol. 75; no. 15_Supplement; p. 2518
• Main Authors: Terhorst, Dorothea, Fossum, Even, Baranska, Anna, Tamoutounour, Samira, Malosse, Camille, Garbani, Mattia, Lechat, Elmira, Crameri, Reto, Winteler, Roland, Bogen, Bjarne, Malissen, Bernard, Henri, Sandrine
• Format: Journal Article
• Language: English
• Published: 01.08.2015

Abstract Background/Aim/Method The induction of CD8+ cytotoxic T lymphocytes (CTL) is critical to eradicate tumor cells. In mouse skin, a subset of dendritic cell characterised by the expression of the chemokine receptor XCR1 is highly potent to activate CD8+ T cells. By combining PLEASE-assisted la...