Abstract 4756: YM155 suppresses survivin expression by disrupting the ILF3/p54nrb transcription factor complex

• Published in: Cancer research (Chicago, Ill.) Vol. 72; no. 8_Supplement; p. 4756
• Main Authors: Nakamura, Naoto, Yamauchi, Tomohiro, Hiramoto, Masashi, Yuri, Masatoshi, Naito, Masanori, Takeuchi, Masahiro, Yamanaka, Kentaro, Nakahara, Takahito, Kita, Aya, Kinoyama, Isao, Matsuhisa, Akira, Sasamata, Masao, Yokota, Hiroyuki, Kawabata, Shigeki, Furuichi, Kiyoshi
• Format: Journal Article
• Language: English
• Published: 15.04.2012

Abstract Survivin, a member of the anti-apoptosis proteins family, is highly expressed in all primary tumor types, and is responsible for cancer progression and drug resistance in many types of cancer. YM155, a small chemical compound, selectively suppressed the expression of survivin and induced ap...