Abstract 2499: Sulfasalazine sensitizes glioblastoma cells to radiation treatment

• Published in: Cancer research (Chicago, Ill.) Vol. 71; no. 8_Supplement; p. 2499
• Main Authors: Sleire, Linda, Wang, Jian, Heggdal, Jan, Pedersen, Paal-Henning, Enger, Per Øyvind
• Format: Journal Article
• Language: English
• Published: 15.04.2011

Abstract Glioblastomas (GBMs) are lethal cancers with a limited response to ionizing radiation. Recent studies suggest that Sulfasalazine (SAS), a drug used to treat inflammatory bowel disease, inhibits the xCT antiporter system in glioma cells, thereby blocking their uptake of cystein. Since the av...