Abstract 2485: The Hippo downstream effector YAP promotes survival, radiation resistance and chromosome instability in medulloblastoma

• Published in: Cancer research (Chicago, Ill.) Vol. 71; no. 8_Supplement; p. 2485
• Main Authors: Fernandez-L, Africa, Kenney, Anna M.
• Format: Journal Article
• Language: English
• Published: 15.04.2011

Abstract Medulloblastoma, the most common solid pediatric tumor, originates in the cerebellum during postnatal development. It is postulated that cerebellar granule neuron precursors (CGNPs) are cells-of-origin for certain classes of medulloblastomas. CGNPs require the mitogen/morphogen Shh to proli...