Abstract 1006: TP53-induced glycolysis and apoptosis regulator (TIGAR) induces NADPH production and growth in nasopharyngeal carcinoma cells

• Published in: Cancer research (Chicago, Ill.) Vol. 71; no. 8_Supplement; p. 1006
• Main Authors: Lam, Emily KY, Lui, Vivian WY, Wong, Elaine YL, Lau, Cecilia PY, Wong, Cesar SC, Hui, Edwin P, Chan, Andrew SK, Tsao, Sai Wah, Mills, Gordon B, Chan, Anthony TC
• Format: Journal Article
• Language: English
• Published: 15.04.2011

Abstract TIGAR (TP53-induced glycolysis and apoptosis regulator) is a novel dual regulator of glycolysis and apoptosis regulated by p53. TIGAR was first found to protect normal cells from oxidative stress by inducing cellular production of NADPH, a powerful reducing agent in the cell, via the pentos...