Abstract 33: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

• Published in: Cancer research (Chicago, Ill.) Vol. 70; no. 8_Supplement; p. 33
• Main Authors: Fantin, Valeria R., Dang, Lenny, White, David W., Gross, Stefan, Bittinger, Mark A., Driggers, Edward M., Jang, Hyun Gyung, Jin, Shengfang, Keenan, Marie C., Marks, Kevin M., Yen, Katharine E., Ward, Patrick S., Prins, Robert M., Liau, Linda M., Bennett, Bryson D., Rabinowitz, Joshua D., Cantley, Lewis C., Thompson, Craig B., Heiden, Matthew Vander, Su, Shinsan M.
• Format: Journal Article
• Language: English
• Published: 15.04.2010

Abstract Mutations in the enzyme isocitrate dehydrogenase 1 (IDH1) are a common feature of most gliomas and secondary glioblastomas, as well as approx 10% acute myeloid leukemias. This event results in loss of the enzyme's ability to catalyze conversion of isocitrate to α -ketoglutarate. Howeve...