Abstract 2493: Inhibition of phosphoinositide 3-kinase suppressed growth of cancer cells with PIK3CA mutations or loss of PTEN expression via G0/G1 arrest of cell cycle but not apoptosis

• Published in: Cancer research (Chicago, Ill.) Vol. 70; no. 8_Supplement; p. 2493
• Main Authors: Dan, Shingo, Okamura, Mutsumi, Yoshimi, Hisashi, Mukai, Yumiko, Yamazaki, Kanami, Inoue, Yasumichi, Hanyu, Aki, Imamura, Takeshi, Sakaue-Sawano, Asako, Miyawaki, Atsushi, Yamori, Takao
• Format: Journal Article
• Language: English
• Published: 15.04.2010

Abstract Background: The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in cancer by gain-of-function mutation of PIK3CA and loss of PTEN expression, and mediates growth- and anti-apoptotic signals. Therefore, PI3K is considered as a promising therapeutic target to inhibit growth a...