Abstract B213: Toward better preclinical combination studies: Using constrained optimization techniques in combination dosage and study design

• Published in: Molecular cancer therapeutics Vol. 12; no. 11_Supplement; p. B213
• Main Authors: Chen, Andrew, Collins, Sabrina, Mettetal, Jerome, Manfredi, Mark, Galvin, Katherine, Shyu, Wen Chyi, Ecsedy, Jeffrey, Palani, Santhosh, Chakravarty, Arijit
• Format: Journal Article
• Language: English
• Published: 01.11.2013

Abstract Dose-limiting toxicities limit the potential of many oncology agents, including targeted therapies. Combination therapies provide a path forward for widening the dose-response window, particularly if efficacy combines in an additive or synergistic manner, while toxicity is subadditive or no...