Targeting Melanocortin 4 Receptor to Treat Sleep-Disordered Breathing

• Published in: Physiology (Bethesda, Md.) Vol. 39; no. S1
• Main Authors: Amorim, Mateus R., Aung, O, Anokye-Danso, Frederick, de Deus, Junia L., Xiong, Jiali, Dergacheva, Olga, Bevans-Fonti, Shannon
• Format: Journal Article
• Language: English
• Published: 01.05.2024

Abstract only There is no effective pharmacotherapy for sleep-disordered breathing (SDB). A melanocortin receptor 4 (MCR4) agonist, setmelanotide (SET), is used to treat genetic obesity caused by abnormal melanocortin and leptin signaling. We hypothesized that SET can treat SDB in diet-induced obese...