POS1245 MORTALITY OF COVID-19 IN PATIENTS WITH RHEUMATIC DISEASES: COMPARISON TO THE GENERAL POPULATION IN MÉXICO
Background: COVID-19 outcomes in Mexican patients with rheumatic diseases (RDs) in comparison to general population patients are unknown. Objectives: To compare mortality and hospitalization of COVID-19 patients with RDs and those without. Methods: We included for this study all the Mexican patients...
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Published in | Annals of the rheumatic diseases Vol. 80; no. Suppl 1; pp. 905 - 906 |
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Main Authors | , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.06.2021
|
Online Access | Get full text |
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Summary: | Background:
COVID-19 outcomes in Mexican patients with rheumatic diseases (RDs) in comparison to general population patients are unknown.
Objectives:
To compare mortality and hospitalization of COVID-19 patients with RDs and those without.
Methods:
We included for this study all the Mexican patients with RDs and COVID-19 registered from April 17
th
to October 30
th
, 2020 in the COVID-19 Global Rheumatology Alliance registry. We compare clinical and demographic characteristics of patients with RDs and COVID-19 to patients with COVID-19 that were selected randomly from the Mexican Epidemiology database (1:3). A logistic regression analysis was performed to adjust for confusion variables.
Results:
We included 322 patients with COVID-19 and RDs and 969 controls without RDs. Table 1 shows the demographic characteristics and comorbidities of both groups. Bivariate analysis showed that patients with RDs had higher mortality, were older, and were more frequently hospitalized. Comorbidities, such as diabetes, hypertension, cardiovascular and renal diseases were also more frequent in patients with RDs. In the multivariate analysis, having a RD was no longer associated with mortality (Figure 1).
Figure 1.
Multivariate analysis of mortality
Conclusion:
Patients with RDs had higher comorbidities, hospitalizations, and mortality than the general population in the bivariate analysis. However, adjusted multivariate analysis showed that the odds for mortality were not increased because of having a RD. These findings suggest that the increased mortality of Mexican patients with RDs may be explained by the higher frequency of comorbidities in this population.
Table 1.
Comparison of patients with COVID-19 with and without RDs
COVID-19 patients without RDs
COVID-19 patients with RDs
p-value
N
969
323
Age (mean (SD))
42.6 (17.4)
51.2 (13.9)
<0.001
Sex = Male (%)
455 (47.0)
55 (17.0)
<0.001
Deceased = Yes (%)
55 (5.7)
43 (13.3)
<0.001
Hospitalization = Hospitalized (%)
164 (16.9)
152 (47.1)
<0.001
Intubation = Yes (%)
27 (2.8)
32 (11.8)
<0.001
COPD_Asthma = Yes (%)
37 (3.8)
15 (4.6)
0.522
Diabetes = Yes (%)
114 (11.8)
49 (15.2)
0.116
Obesity = Yes (%)
128 (13.3)
21 (6.5)
0.001
Hypertension = Yes (%)
152 (15.8)
88 (27.2)
<0.001
Cardiovascular disease = Yes (%)
19 (2.0)
14 (4.3)
0.02
CRF = Yes (%)
22 (2.3)
17 (5.3)
0.007
Pregnancy = Yes (%)
5 (0.5)
2 (0.6)
0.827
Smoker = Yes (%)
86 (8.9)
10 (3.1)
0.001
Abbreviations: RDs, rheumatic diseases; COPD, chronic obstructive pulmonary disease; CRF, chronic renal failure.
Disclosure of Interests:
None declared |
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ISSN: | 0003-4967 1468-2060 |
DOI: | 10.1136/annrheumdis-2021-eular.3447 |