Effect of Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia: A Randomized Clinical Trial
Abstract Background The addition of dexmedetomidine or nalbuphine to epidural bupivacaine was tested to reduce labor pain in women undergoing normal delivery. Patients and Methods 64 patients were randomly allocated into two groups of 32 parturients each with conscent from parturients. Groups A and...
Saved in:
Published in | QJM : An International Journal of Medicine Vol. 116; no. Supplement_1 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
23.08.2023
|
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract
Background
The addition of dexmedetomidine or nalbuphine to epidural bupivacaine was tested to reduce labor pain in women undergoing normal delivery.
Patients and Methods
64 patients were randomly allocated into two groups of 32 parturients each with conscent from parturients. Groups A and B received a bolus of 12 ml volume consisting of 11 ml of 0.25% bupivacaine and 0.5 μg/ml dexmedetomidine (1 ml volume) through the epidural catheter and then a top up dose of 6 ml volume consisting of 5 ml of 0.25% bupivacaine and 0.5 μg/ml dexmedetomidine (1 ml volume) were given when VAS score becomes 4 or more and a bolus of 12 ml volume consisting of 11 ml of 0.25% bupivacaine and 10 mg nalbuphine (1 ml volume) through the epidural catheter and then a top up dose of 5 ml of 0.25% bupivacaine and 2 mg nalbuphine (1 ml volume) respectively. Assessments included VAS score for pain, vital data monitoring, recording of duration of stages of labor, neonatal APGAR score and adverse effects.
Results
Parturients in both groups had satisfactory labor analgesia, but those in the dexmedetomidine group had lower pain scores than those in the nalbuphine group. Taking into consideration that dexmedetomidine had a faster onset than nalbuphine.
Conclusion
Epidural dexmedetomidine seems to offer some advantages over epidural nalbuphine.
Thus, it can be used effectively and safely as an adjuvant to epidural bupivacaine in labor analgesia. |
---|---|
AbstractList | Abstract
Background
The addition of dexmedetomidine or nalbuphine to epidural bupivacaine was tested to reduce labor pain in women undergoing normal delivery.
Patients and Methods
64 patients were randomly allocated into two groups of 32 parturients each with conscent from parturients. Groups A and B received a bolus of 12 ml volume consisting of 11 ml of 0.25% bupivacaine and 0.5 μg/ml dexmedetomidine (1 ml volume) through the epidural catheter and then a top up dose of 6 ml volume consisting of 5 ml of 0.25% bupivacaine and 0.5 μg/ml dexmedetomidine (1 ml volume) were given when VAS score becomes 4 or more and a bolus of 12 ml volume consisting of 11 ml of 0.25% bupivacaine and 10 mg nalbuphine (1 ml volume) through the epidural catheter and then a top up dose of 5 ml of 0.25% bupivacaine and 2 mg nalbuphine (1 ml volume) respectively. Assessments included VAS score for pain, vital data monitoring, recording of duration of stages of labor, neonatal APGAR score and adverse effects.
Results
Parturients in both groups had satisfactory labor analgesia, but those in the dexmedetomidine group had lower pain scores than those in the nalbuphine group. Taking into consideration that dexmedetomidine had a faster onset than nalbuphine.
Conclusion
Epidural dexmedetomidine seems to offer some advantages over epidural nalbuphine.
Thus, it can be used effectively and safely as an adjuvant to epidural bupivacaine in labor analgesia. |
Author | EL Kabarity, Reem Hamdy Ahmed, Nourhan Tarek Fouad El Fawal, Sanaa Mohammed Abd El Tawab, Samar Mohammed |
Author_xml | – sequence: 1 givenname: Reem Hamdy surname: EL Kabarity fullname: EL Kabarity, Reem Hamdy – sequence: 2 givenname: Sanaa Mohammed surname: El Fawal fullname: El Fawal, Sanaa Mohammed – sequence: 3 givenname: Samar Mohammed surname: Abd El Tawab fullname: Abd El Tawab, Samar Mohammed – sequence: 4 givenname: Nourhan Tarek Fouad surname: Ahmed fullname: Ahmed, Nourhan Tarek Fouad |
BookMark | eNqdj81OAjEUhRuDiaA-gLv7AsAtMzKMO4JjWBgXhn1zmd5KSacdWzDq01sMvoCb87M4J_lGYuCDZyHuJE4k1sX0fd-xnu5a0jivJ7ioLsRQlnMcz4q6GPzlanZ_JUYp7RGxrMrFUFBjDLcHCAaa3upjJAeP_JnP-BA6q61n-EjwQm577HenZkKEZ9pmXXpyb5wsPcASXsnrPPhmDStnvW3z0SZacjfi0pBLfHv2ayGfms1qPW5jSCmyUX20HcUvJVGdWNQvizqzqMxS_GfzA3-RWF8 |
ContentType | Journal Article |
DBID | AAYXX CITATION |
DOI | 10.1093/qjmed/hcad069.087 |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1460-2393 |
ExternalDocumentID | 10_1093_qjmed_hcad069_087 |
GroupedDBID | --- -E4 .2P .I3 .XZ .ZR 08G 0R~ 123 18M 29P 2WC 4.4 482 48X 5RE 5VS 5WA 5WD 70D 8F7 AABZA AACZT AAJKP AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AASNB AAUAY AAVAP AAYEP AAYXX ABEUO ABIXL ABJNI ABKDP ABLJU ABNHQ ABNKS ABOCM ABPTD ABQLI ABQNK ABWST ABXVV ABZBJ ACGFS ACUFI ACUTJ ACUTO ACYHN ADBBV ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEJOX AEKSI AEMDU AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFXAL AFXEN AGINJ AGKEF AGQXC AGSYK AGUTN AHMBA AHXPO AIJHB AJEEA AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APWMN ATGXG AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM C45 CDBKE CITATION CS3 CZ4 DAKXR DIK DILTD D~K E3Z EBS EE~ EMOBN ENERS F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HZ~ IOX J21 JXSIZ KAQDR KOP KQ8 KSI KSN M-Z M49 MHKGH ML0 N9A NGC NOMLY NOYVH NU- O9- OAUYM OAWHX OB2 OCZFY ODMLO OHH OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q1. Q5Y R44 RD5 RHF RIG ROL ROX ROZ RUSNO RW1 RXO TCURE TEORI TJX TR2 VVN W8F WH7 WOQ X7H YAYTL YKOAZ YOC YXANX ZKX ~91 |
ID | FETCH-crossref_primary_10_1093_qjmed_hcad069_0873 |
ISSN | 1460-2725 |
IngestDate | Thu Sep 12 19:33:54 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | Supplement_1 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-crossref_primary_10_1093_qjmed_hcad069_0873 |
ParticipantIDs | crossref_primary_10_1093_qjmed_hcad069_087 |
PublicationCentury | 2000 |
PublicationDate | 2023-08-23 |
PublicationDateYYYYMMDD | 2023-08-23 |
PublicationDate_xml | – month: 08 year: 2023 text: 2023-08-23 day: 23 |
PublicationDecade | 2020 |
PublicationTitle | QJM : An International Journal of Medicine |
PublicationYear | 2023 |
SSID | ssj0004748 |
Score | 4.892045 |
Snippet | Abstract
Background
The addition of dexmedetomidine or nalbuphine to epidural bupivacaine was tested to reduce labor pain in women undergoing normal delivery.... |
SourceID | crossref |
SourceType | Aggregation Database |
Title | Effect of Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia: A Randomized Clinical Trial |
Volume | 116 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwELa6IKG9IGBBvOUDp41SmjhtKDfEtlRAkRaC1FvkxA4pkLRAeYh_yL_aGTsvKpBgL1FquSMn35fxaDwPQnaipiWj0A3Nxl4YmE7EQpMDzvDFCyZhh-BRE5OT-2et3qVzPGgOarW3StTS4ySoh68f5pX8D6owBrhiluw3kC2EwgDcA75wBYTh-iWMs9LDGBw4HgpVQOOPfIH9TU5GyVCgAfkEegxDkMcx_sKYwlOEXRUjuZIPQ65T0895KuAvr-jvzXMlPXyCqvH697hvfOpIzKza_tRZfefUOMGogaz5wLmUidHjiSg8-Z1bo8ufVdsB44KnnIOaidGdLsqTKWHALA9mBXpWgsWHpmfFifbbnsFiYtBaHr-XN9g2iouqa8Nm6KvV2ceZNnZaDdN2dWZ0XVbGmG6rWKhwna-ZcVX1Q1XOVd_6cJfQFbTurtW6unHIRaPVrjeynf9dTe6pvbKIYNRn98xXQvxMhA8ifpBZ2203Mbr0aFBGGzmuauRWPFF-wN5mu0rEbmUVFROpYut4C2Q-g5MeaMYtkppMl8hcDu0vwjXx6CiiOfHoFPHo0wMtiUeBeFQRjxbE26cHtKQdzWlHFe2WidXteIc9M1-iP9ZlUfxPXwlbITPpKJWrhDLXsrnrhHYgsdQkxj5LyRloi2jPtiJrjfz-utz170zeID9Lim2Smcn9o9wCe3ISbCuk_gHNWX9V |
link.rule.ids | 315,786,790,27955,27956 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+Epidural+Dexmedetomidine+vs+Nalbuphine+for+Labor+Analgesia%3A+A+Randomized+Clinical+Trial&rft.jtitle=QJM+%3A+An+International+Journal+of+Medicine&rft.au=EL+Kabarity%2C+Reem+Hamdy&rft.au=El+Fawal%2C+Sanaa+Mohammed&rft.au=Abd+El+Tawab%2C+Samar+Mohammed&rft.au=Ahmed%2C+Nourhan+Tarek+Fouad&rft.date=2023-08-23&rft.issn=1460-2725&rft.eissn=1460-2393&rft.volume=116&rft.issue=Supplement_1&rft_id=info:doi/10.1093%2Fqjmed%2Fhcad069.087&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_qjmed_hcad069_087 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1460-2725&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1460-2725&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1460-2725&client=summon |