CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models CXCR4 Inhibition Has Anti-Tumor and Anti-Metastatic Effects in Prostate Cancer Models

Saved in:
Bibliographic Details
Published inThe Prostate Vol. 75; no. 12; pp. 1227 - 1246
Main Authors Gravina, Giovanni Luca, Mancini, Andrea, Muzi, Paola, Ventura, Luca, Biordi, Leda, Ricevuto, Enrico, Pompili, Simona, Mattei, Claudia, Di Cesare, Ernesto, Jannini, Emmanuele A., Festuccia, Claudio
Format Journal Article
LanguageEnglish
Published 01.07.2015
Online AccessGet full text

Cover

Author Mattei, Claudia
Biordi, Leda
Pompili, Simona
Ricevuto, Enrico
Ventura, Luca
Di Cesare, Ernesto
Festuccia, Claudio
Gravina, Giovanni Luca
Muzi, Paola
Jannini, Emmanuele A.
Mancini, Andrea
Author_xml – sequence: 1
  givenname: Giovanni Luca
  surname: Gravina
  fullname: Gravina, Giovanni Luca
  organization: Division of Radiation Oncology; Department of Biotechnological and Applied Clinical Sciences; University of L'Aquila; L'Aquila Italy, Department of Biotechnological and Applied Clinical Sciences; Laboratory of Radiobiology; University of L'Aquila; L'Aquila Italy
– sequence: 2
  givenname: Andrea
  surname: Mancini
  fullname: Mancini, Andrea
  organization: Department of Biotechnological and Applied Clinical Sciences; Laboratory of Radiobiology; University of L'Aquila; L'Aquila Italy
– sequence: 3
  givenname: Paola
  surname: Muzi
  fullname: Muzi, Paola
  organization: Department of Life; Health and Environmental Sciences; L'Aquila Italy
– sequence: 4
  givenname: Luca
  surname: Ventura
  fullname: Ventura, Luca
  organization: Pathology Department; San Salvatore Hospital L'Aquila; L'Aquila Italy
– sequence: 5
  givenname: Leda
  surname: Biordi
  fullname: Biordi, Leda
  organization: Department of Biotechnological and Applied Clinical Sciences; Laboratory of Molecular Pathology; University of L'Aquila; L'Aquila Italy
– sequence: 6
  givenname: Enrico
  surname: Ricevuto
  fullname: Ricevuto, Enrico
  organization: Department of Biotechnological and Applied Clinical Sciences; Laboratory of Molecular Pathology; University of L'Aquila; L'Aquila Italy
– sequence: 7
  givenname: Simona
  surname: Pompili
  fullname: Pompili, Simona
  organization: Department of Biotechnological and Applied Clinical Sciences; Laboratory of Human Anatomy; L'Aquila Italy
– sequence: 8
  givenname: Claudia
  surname: Mattei
  fullname: Mattei, Claudia
  organization: Department of Biotechnological and Applied Clinical Sciences; Laboratory of Radiobiology; University of L'Aquila; L'Aquila Italy
– sequence: 9
  givenname: Ernesto
  surname: Di Cesare
  fullname: Di Cesare, Ernesto
  organization: Division of Radiation Oncology; Department of Biotechnological and Applied Clinical Sciences; University of L'Aquila; L'Aquila Italy, Department of Biotechnological and Applied Clinical Sciences; Laboratory of Radiobiology; University of L'Aquila; L'Aquila Italy
– sequence: 10
  givenname: Emmanuele A.
  surname: Jannini
  fullname: Jannini, Emmanuele A.
  organization: Department of Systems Medicine; University of Tor Vergata; Roma Italy
– sequence: 11
  givenname: Claudio
  surname: Festuccia
  fullname: Festuccia, Claudio
  organization: Department of Biotechnological and Applied Clinical Sciences; Laboratory of Radiobiology; University of L'Aquila; L'Aquila Italy
BookMark eNqVj0FOw0AMRWdRJFpg0xN4jdTiJJVygKiINWLBLppMnMQo8UQzjlBPxDWZRFyAlWXrv-__D2YnXsiYY4bnDDF_mYOP57xALHdmj3mJp0tWlPfmEOMXYpJgvjc_1Wf1foF5sGGyzvfs7AgsAzes7AUCtYujCE3yBistRN8pKMe4EEykNqpVdtAsoSWB5ga268gpSw-6TD5AH_y3Dhu7HbgnScDslUR5-wZr1ORD4Kw4CmknN7JsYSbf0hgfzV1nx0hPf_PBPL9eP6q3k0toDNTVc-DJhludYb3Wr1fPeqtf_Ev8C6YDawQ
Cites_doi 10.3748/wjg.v17.i19.2389
10.1158/1541-7786.MCR-07-0117
10.1677/erc.1.01100
10.1042/CBI20100744
10.1006/excr.2002.5609
10.1186/1476-4598-5-56
10.1002/pros.21008
10.1016/j.ejca.2010.09.028
10.1677/ERC-07-0118
10.1016/j.oraloncology.2012.01.006
10.1593/neo.12324
10.2741/2311
10.1158/1078-0432.CCR-05-2050
10.1002/path.2908
10.1038/6495
10.1158/1078-0432.CCR-05-1671
10.1359/JBMR.041109
10.1182/blood-2008-06-162123
10.1186/1471-2490-14-12
10.1002/pros.1065
10.1158/1541-7786.MCR-13-0029-T
10.1093/jnci/85.5.394
10.1007/s00418-012-0998-0
10.1002/pros.10290
10.1016/j.ejca.2009.12.014
10.1111/j.1349-7006.2007.00712.x
10.1371/journal.pone.0047287
10.1038/onc.2009.298
10.1016/j.urolonc.2007.05.010
10.1096/fj.03-0935fje
10.2174/138161210794455003
10.1016/S0959-8049(00)00436-6
10.3892/ijo.2013.1892
10.1007/s12032-013-0674-9
10.3892/or.2012.2028
10.1002/pros.21140
10.1002/pros.20500
10.1186/1756-8722-7-46
10.1002/pros.20318
10.1182/blood-2011-10-383406
10.1593/neo.05694
10.1016/j.ejca.2011.05.006
10.1016/j.ejca.2006.06.024
10.1530/ERC-11-0045
10.2174/092986711797287539
10.1111/j.1349-7006.2012.02200.x
10.1016/j.jss.2008.06.044
10.1158/0008-5472.CAN-04-1844
10.1016/j.ejcb.2012.04.005
10.4161/cam.21559
10.1158/0008-5472.CAN-10-1146
10.1016/j.jss.2012.09.035
ContentType Journal Article
DBID AAYXX
CITATION
DOI 10.1002/pros.23007
DatabaseName CrossRef
DatabaseTitle CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EndPage 1246
ExternalDocumentID 10_1002_pros_23007
GroupedDBID ---
.3N
.GA
.GJ
.Y3
05W
0R~
10A
123
1L6
1OB
1OC
1ZS
31~
33P
3O-
3SF
3WU
4.4
4ZD
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHHS
AANLZ
AAONW
AASGY
AAXRX
AAYXX
AAZKR
ABCQN
ABCUV
ABEML
ABIJN
ABJNI
ABLJU
ABPVW
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACFBH
ACGFS
ACGOF
ACMXC
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADZMN
AEEZP
AEGXH
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFFNX
AFFPM
AFGKR
AFPWT
AFZJQ
AHBTC
AHMBA
AIACR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BY8
C45
CITATION
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
EBD
EBS
EJD
EMOBN
F00
F01
F04
F5P
FEDTE
FUBAC
G-S
G.N
GNP
GODZA
H.X
HBH
HF~
HGLYW
HHY
HHZ
HVGLF
HZ~
IX1
J0M
JPC
KBYEO
KQQ
LATKE
LAW
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
M6P
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
NNB
O66
O9-
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
QRW
R.K
RIWAO
RJQFR
ROL
RWI
RX1
RYL
SAMSI
SUPJJ
SV3
TEORI
UB1
V2E
W8V
W99
WBKPD
WHWMO
WIB
WIH
WIJ
WIK
WJL
WOHZO
WQJ
WRC
WUP
WVDHM
WWO
WXI
WXSBR
XG1
XV2
ZGI
ZXP
ZZTAW
~IA
~WT
ID FETCH-crossref_primary_10_1002_pros_230073
ISSN 0270-4137
IngestDate Fri Aug 23 02:11:38 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 12
Language English
LinkModel OpenURL
MergedId FETCHMERGED-crossref_primary_10_1002_pros_230073
ParticipantIDs crossref_primary_10_1002_pros_23007
PublicationCentury 2000
PublicationDate 2015-07-00
PublicationDateYYYYMMDD 2015-07-01
PublicationDate_xml – month: 07
  year: 2015
  text: 2015-07-00
PublicationDecade 2010
PublicationTitle The Prostate
PublicationYear 2015
References Domanska UM1 (10.1002/pros.23007-BIB0055|pros23007-cit-0055) 2012; 14
van Bokhoven (10.1002/pros.23007-BIB0047|pros23007-cit-0047) 2003; 57
Festuccia (10.1002/pros.23007-BIB0050|pros23007-cit-0050) 1995; 7
Schulte (10.1002/pros.23007-BIB0067|pros23007-cit-0067) 2012; 138
Li (10.1002/pros.23007-BIB0019|pros23007-cit-0019) 2012; 48
Angelucci (10.1002/pros.23007-BIB0048|pros23007-cit-0048) 2006; 42
Ye (10.1002/pros.23007-BIB0002|pros23007-cit-0002) 2007; 2
Festuccia (10.1002/pros.23007-BIB0007|pros23007-cit-0007) 1999; 11
Wong (10.1002/pros.23007-BIB0037|pros23007-cit-0037) 2014; 14
Angelucci (10.1002/pros.23007-BIB0039|pros23007-cit-0039) 2006; 13
Feng (10.1002/pros.23007-BIB0025|pros23007-cit-0025) 2011; 47
Huang (10.1002/pros.23007-BIB0030|pros23007-cit-0030) 2009; 155
Zhao (10.1002/pros.23007-BIB0033|pros23007-cit-0033) 2011; 17
Festuccia (10.1002/pros.23007-BIB0009|pros23007-cit-0009) 1997; 9
Festuccia (10.1002/pros.23007-BIB0051|pros23007-cit-0051) 2007; 14
Yu (10.1002/pros.23007-BIB0068|pros23007-cit-0068) 2013; 30
Hasegawa (10.1002/pros.23007-BIB0058|pros23007-cit-0058) 2012; 30
Lee (10.1002/pros.23007-BIB0056|pros23007-cit-0056) 2010; 29
Perez (10.1002/pros.23007-BIB0008|pros23007-cit-0008) 2001; 37
Darash-Yahana (10.1002/pros.23007-BIB0010|pros23007-cit-0010) 2004; 18
Angelucci (10.1002/pros.23007-BIB0038|pros23007-cit-0038) 2004; 25
Hadaschik (10.1002/pros.23007-BIB0003|pros23007-cit-0003) 2007; 25
Ping (10.1002/pros.23007-BIB0017|pros23007-cit-0017) 2011; 224
Engl (10.1002/pros.23007-BIB0021|pros23007-cit-0021) 2006; 8
Porvasnik (10.1002/pros.23007-BIB0061|pros23007-cit-0061) 2009; 69
Drenckhan (10.1002/pros.23007-BIB0029|pros23007-cit-0029) 2013; 182
Smith (10.1002/pros.23007-BIB0011|pros23007-cit-0011) 2004; 64
Pan (10.1002/pros.23007-BIB0014|pros23007-cit-0014) 2006; 5
Chinni (10.1002/pros.23007-BIB0036|pros23007-cit-0036) 2008; 6
Wang (10.1002/pros.23007-BIB0018|pros23007-cit-0018) 2011; 35
Lin (10.1002/pros.23007-BIB0035|pros23007-cit-0035) 2010; 70
Craft (10.1002/pros.23007-BIB0042|pros23007-cit-0042) 1999; 5
Uy (10.1002/pros.23007-BIB0027|pros23007-cit-0027) 2012; 119
Lin (10.1002/pros.23007-BIB0041|pros23007-cit-0041) 2001; 47
Hatano (10.1002/pros.23007-BIB0066|pros23007-cit-0066) 2013; 11
Larsson (10.1002/pros.23007-BIB0004|pros23007-cit-0004) 2011; 18
Arya (10.1002/pros.23007-BIB0013|pros23007-cit-0013) 2004; 4
Akashi (10.1002/pros.23007-BIB0012|pros23007-cit-0012) 2008; 99
Liekens (10.1002/pros.23007-BIB0016|pros23007-cit-0016) 2010; 16
Chinni (10.1002/pros.23007-BIB0020|pros23007-cit-0020) 2006; 66
Pretlow (10.1002/pros.23007-BIB0043|pros23007-cit-0043) 1993; 85
Festuccia (10.1002/pros.23007-BIB0049|pros23007-cit-0049) 2002; 280
Uchida (10.1002/pros.23007-BIB0062|pros23007-cit-0062) 2011; 47
Sun (10.1002/pros.23007-BIB0063|pros23007-cit-0063) 2005; 20
Domanska (10.1002/pros.23007-BIB0028|pros23007-cit-0028) 2012; 14
Uchida (10.1002/pros.23007-BIB0032|pros23007-cit-0032) 2011; 47
Bruzzese (10.1002/pros.23007-BIB0053|pros23007-cit-0053) 2006; 12
Taichman (10.1002/pros.23007-BIB0015|pros23007-cit-0015) 2002; 62
Gravina (10.1002/pros.23007-BIB0052|pros23007-cit-0052) 2011; 18
Pettaway CA1 (10.1002/pros.23007-BIB0040|pros23007-cit-0040) 1996; 2
Ping (10.1002/pros.23007-BIB0057|pros23007-cit-0057) 2011; 224
Ferlay (10.1002/pros.23007-BIB0001|pros23007-cit-0001) 2010; 46
Wang (10.1002/pros.23007-BIB0024|pros23007-cit-0024) 2012; 28
Nervi (10.1002/pros.23007-BIB0026|pros23007-cit-0026) 2009; 113
Korenchuk (10.1002/pros.23007-BIB0044|pros23007-cit-0044) 2001; 15
Richert (10.1002/pros.23007-BIB0060|pros23007-cit-0060) 2009; 21
Addadi (10.1002/pros.23007-BIB0059|pros23007-cit-0059) 2010; 70
Gros (10.1002/pros.23007-BIB0034|pros23007-cit-0034) 2012; 7
Porvasnik (10.1002/pros.23007-BIB0065|pros23007-cit-0065) 2009; 69
Matsui (10.1002/pros.23007-BIB0023|pros23007-cit-0023) 2012; 103
Yamaguchi (10.1002/pros.23007-BIB0006|pros23007-cit-0006) 2012; 91
Yang (10.1002/pros.23007-BIB0054|pros23007-cit-0054) 2006; 12
Porvasnik (10.1002/pros.23007-BIB0031|pros23007-cit-0031) 2009; 69
Sun (10.1002/pros.23007-BIB0022|pros23007-cit-0022) 2007; 67
Bradbury (10.1002/pros.23007-BIB0005|pros23007-cit-0005) 2012; 6
Gravina (10.1002/pros.23007-BIB0045|pros23007-cit-0045) 2013; 42
Gravina (10.1002/pros.23007-BIB0046|pros23007-cit-0046) 2014; 7
Huang (10.1002/pros.23007-BIB0064|pros23007-cit-0064) 2009; 155
References_xml – volume: 17
  start-page: 2389
  year: 2011
  ident: 10.1002/pros.23007-BIB0033|pros23007-cit-0033
  article-title: CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v17.i19.2389
  contributor:
    fullname: Zhao
– volume: 6
  start-page: 446
  year: 2008
  ident: 10.1002/pros.23007-BIB0036|pros23007-cit-0036
  article-title: CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone
  publication-title: Mol Cancer Res .
  doi: 10.1158/1541-7786.MCR-07-0117
  contributor:
    fullname: Chinni
– volume: 13
  start-page: 197
  year: 2006
  ident: 10.1002/pros.23007-BIB0039|pros23007-cit-0039
  article-title: Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice
  publication-title: Endocr Relat Cancer
  doi: 10.1677/erc.1.01100
  contributor:
    fullname: Angelucci
– volume: 15
  start-page: 163
  year: 2001
  ident: 10.1002/pros.23007-BIB0044|pros23007-cit-0044
  article-title: VCaP, a cell-based model system of human prostate cancer
  publication-title: In Vivo
  contributor:
    fullname: Korenchuk
– volume: 25
  start-page: 1713
  year: 2004
  ident: 10.1002/pros.23007-BIB0038|pros23007-cit-0038
  article-title: Evaluation of metastatic potential in prostate carcinoma: An in vivo model
  publication-title: Int J Oncol
  contributor:
    fullname: Angelucci
– volume: 35
  start-page: 897
  year: 2011
  ident: 10.1002/pros.23007-BIB0018|pros23007-cit-0018
  article-title: Regulation of VEGF, MMP-9 and metastasis by CXCR4 in a prostate cancer cell line
  publication-title: Cell Biol Int
  doi: 10.1042/CBI20100744
  contributor:
    fullname: Wang
– volume: 280
  start-page: 1
  year: 2002
  ident: 10.1002/pros.23007-BIB0049|pros23007-cit-0049
  article-title: Bombesindependent pro-MMP-9 activation in prostatic cancer cells requires beta1 integrin engagement
  publication-title: Exp Cell Res
  doi: 10.1006/excr.2002.5609
  contributor:
    fullname: Festuccia
– volume: 5
  start-page: 56
  year: 2006
  ident: 10.1002/pros.23007-BIB0014|pros23007-cit-0014
  article-title: Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
  publication-title: Mol Cancer
  doi: 10.1186/1476-4598-5-56
  contributor:
    fullname: Pan
– volume: 69
  start-page: 1460
  year: 2009
  ident: 10.1002/pros.23007-BIB0031|pros23007-cit-0031
  article-title: Effects of CXCR4 antagonist CTCE-9908 on prostate tumour growth
  publication-title: Prostate
  doi: 10.1002/pros.21008
  contributor:
    fullname: Porvasnik
– volume: 47
  start-page: 452
  year: 2011
  ident: 10.1002/pros.23007-BIB0032|pros23007-cit-0032
  article-title: Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2010.09.028
  contributor:
    fullname: Uchida
– volume: 14
  start-page: 601
  year: 2007
  ident: 10.1002/pros.23007-BIB0051|pros23007-cit-0051
  article-title: Bicalutamide increases phospho-Akt levels through Her2 in patients with prostate cancer
  publication-title: Endocr Relat Cancer
  doi: 10.1677/ERC-07-0118
  contributor:
    fullname: Festuccia
– volume: 62
  start-page: 1832
  year: 2002
  ident: 10.1002/pros.23007-BIB0015|pros23007-cit-0015
  article-title: Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
  publication-title: Cancer Res
  contributor:
    fullname: Taichman
– volume: 48
  start-page: 507
  year: 2012
  ident: 10.1002/pros.23007-BIB0019|pros23007-cit-0019
  article-title: The role of IL-8 in the SDF-1α/CXCR4-induced angiogenesis of laryngeal and hypopharyngeal squamous cell carcinoma
  publication-title: Oral Oncol
  doi: 10.1016/j.oraloncology.2012.01.006
  contributor:
    fullname: Li
– volume: 14
  start-page: 709
  year: 2012
  ident: 10.1002/pros.23007-BIB0055|pros23007-cit-0055
  article-title: CXCR4 inhibition with AMD3100 sensitizes prostate cancer to docetaxel chemotherapy
  publication-title: Neoplasia .
  doi: 10.1593/neo.12324
  contributor:
    fullname: Domanska UM1
– volume: 2
  start-page: 3273
  year: 2007
  ident: 10.1002/pros.23007-BIB0002|pros23007-cit-0002
  article-title: Biology and clinical management of prostate cancer bone metastasis
  publication-title: Front Biosci
  doi: 10.2741/2311
  contributor:
    fullname: Ye
– volume: 12
  start-page: 2602
  year: 2006
  ident: 10.1002/pros.23007-BIB0054|pros23007-cit-0054
  article-title: The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-05-2050
  contributor:
    fullname: Yang
– volume: 224
  start-page: 344
  year: 2011
  ident: 10.1002/pros.23007-BIB0017|pros23007-cit-0017
  article-title: The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling
  publication-title: J Pathol
  doi: 10.1002/path.2908
  contributor:
    fullname: Ping
– volume: 5
  start-page: 280
  year: 1999
  ident: 10.1002/pros.23007-BIB0042|pros23007-cit-0042
  article-title: A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
  publication-title: Nat Med
  doi: 10.1038/6495
  contributor:
    fullname: Craft
– volume: 12
  start-page: 617
  year: 2006
  ident: 10.1002/pros.23007-BIB0053|pros23007-cit-0053
  article-title: Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head and neck cancer cells in vitro and in vivo
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-05-1671
  contributor:
    fullname: Bruzzese
– volume: 20
  start-page: 318
  year: 2005
  ident: 10.1002/pros.23007-BIB0063|pros23007-cit-0063
  article-title: Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo
  publication-title: J Bone Miner Res
  doi: 10.1359/JBMR.041109
  contributor:
    fullname: Sun
– volume: 113
  start-page: 6206
  issue: 24
  year: 2009
  ident: 10.1002/pros.23007-BIB0026|pros23007-cit-0026
  article-title: Mobilisation and chemosensitisation of AML with the CXCR4 antagonist plerixafor (AMD3100): A phase I/II study of AMD3100 + MEC in patients with relapsed or refractory disease
  publication-title: Blood
  doi: 10.1182/blood-2008-06-162123
  contributor:
    fullname: Nervi
– volume: 9
  start-page: 419
  year: 1997
  ident: 10.1002/pros.23007-BIB0009|pros23007-cit-0009
  article-title: Human prostatic tumour cells in culture produce growth and differentiation factors active on osteoblasts: A new biological and clinical parameter for prostatic carcinoma
  publication-title: Oncol Res
  contributor:
    fullname: Festuccia
– volume: 14
  start-page: 12
  year: 2014
  ident: 10.1002/pros.23007-BIB0037|pros23007-cit-0037
  article-title: Targeting CXCR4 with CTCE-9908 inhibits prostate tumor metastasis
  publication-title: BMC Urol
  doi: 10.1186/1471-2490-14-12
  contributor:
    fullname: Wong
– volume: 47
  start-page: 212
  year: 2001
  ident: 10.1002/pros.23007-BIB0041|pros23007-cit-0041
  article-title: Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro
  publication-title: Prostate
  doi: 10.1002/pros.1065
  contributor:
    fullname: Lin
– volume: 11
  start-page: 1088
  year: 2013
  ident: 10.1002/pros.23007-BIB0066|pros23007-cit-0066
  article-title: Residual prostate cancer cells after docetaxel therapy increase the tumorigenic potential via constitutive signaling of CXCR4, ERK1/2 and c-Myc
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-13-0029-T
  contributor:
    fullname: Hatano
– volume: 85
  start-page: 394
  year: 1993
  ident: 10.1002/pros.23007-BIB0043|pros23007-cit-0043
  article-title: Xenografts of primary human prostatic carcinoma
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/85.5.394
  contributor:
    fullname: Pretlow
– volume: 138
  start-page: 847
  year: 2012
  ident: 10.1002/pros.23007-BIB0067|pros23007-cit-0067
  article-title: Expression of the E-cadherin repressors Snail, Slug and Zeb1 in urothelial carcinoma of the urinary bladder: Relation to stromal fibroblast activation and invasive behaviour of carcinoma cells
  publication-title: Histochem Cell Biol
  doi: 10.1007/s00418-012-0998-0
  contributor:
    fullname: Schulte
– volume: 57
  start-page: 205
  year: 2003
  ident: 10.1002/pros.23007-BIB0047|pros23007-cit-0047
  article-title: Molecular characterization of human prostate carcinoma cell lines
  publication-title: Prostate
  doi: 10.1002/pros.10290
  contributor:
    fullname: van Bokhoven
– volume: 46
  start-page: 765
  year: 2010
  ident: 10.1002/pros.23007-BIB0001|pros23007-cit-0001
  article-title: Estimates of cancer incidence and mortality in Europe in 2008
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2009.12.014
  contributor:
    fullname: Ferlay
– volume: 99
  start-page: 539
  year: 2008
  ident: 10.1002/pros.23007-BIB0012|pros23007-cit-0012
  article-title: Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2007.00712.x
  contributor:
    fullname: Akashi
– volume: 47
  start-page: 452
  year: 2011
  ident: 10.1002/pros.23007-BIB0062|pros23007-cit-0062
  article-title: Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2010.09.028
  contributor:
    fullname: Uchida
– volume: 2
  start-page: 1627
  year: 1996
  ident: 10.1002/pros.23007-BIB0040|pros23007-cit-0040
  article-title: Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice
  publication-title: Clin Cancer Res
  contributor:
    fullname: Pettaway CA1
– volume: 7
  start-page: 131
  year: 1995
  ident: 10.1002/pros.23007-BIB0050|pros23007-cit-0050
  article-title: Plasminogen activator activities in short-term tissue cultures of benign prostatic hyperplasia and prostatic carcinoma
  publication-title: Oncol Res
  contributor:
    fullname: Festuccia
– volume: 224
  start-page: 344
  year: 2011
  ident: 10.1002/pros.23007-BIB0057|pros23007-cit-0057
  article-title: The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling
  publication-title: J Pathol
  doi: 10.1002/path.2908
  contributor:
    fullname: Ping
– volume: 7
  start-page: e47287
  issue: 10
  year: 2012
  ident: 10.1002/pros.23007-BIB0034|pros23007-cit-0034
  article-title: Involvement of CXCR4 chemokine receptor in metastatic HER2-positive oesophageal cancer
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0047287
  contributor:
    fullname: Gros
– volume: 29
  start-page: 56
  year: 2010
  ident: 10.1002/pros.23007-BIB0056|pros23007-cit-0056
  article-title: PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression
  publication-title: Oncogene
  doi: 10.1038/onc.2009.298
  contributor:
    fullname: Lee
– volume: 69
  start-page: 1460
  year: 2009
  ident: 10.1002/pros.23007-BIB0061|pros23007-cit-0061
  article-title: Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth
  publication-title: Prostate
  doi: 10.1002/pros.21008
  contributor:
    fullname: Porvasnik
– volume: 25
  start-page: 413
  year: 2007
  ident: 10.1002/pros.23007-BIB0003|pros23007-cit-0003
  article-title: Therapeutic options for hormone-refractory prostate cancer in
  publication-title: Urol Oncol
  doi: 10.1016/j.urolonc.2007.05.010
  contributor:
    fullname: Hadaschik
– volume: 18
  start-page: 1240
  year: 2004
  ident: 10.1002/pros.23007-BIB0010|pros23007-cit-0010
  article-title: Role of high expression levels of CXCR4 in tumour growth, vascularisation, and metastasis
  publication-title: FASEB J
  doi: 10.1096/fj.03-0935fje
  contributor:
    fullname: Darash-Yahana
– volume: 16
  start-page: 3903
  year: 2010
  ident: 10.1002/pros.23007-BIB0016|pros23007-cit-0016
  article-title: CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization
  publication-title: Curr Pharm Des
  doi: 10.2174/138161210794455003
  contributor:
    fullname: Liekens
– volume: 37
  start-page: 629
  year: 2001
  ident: 10.1002/pros.23007-BIB0008|pros23007-cit-0008
  article-title: Melanoma cells stimulate osteoclastogenesis, c-Src expression and osteoblast cytokines
  publication-title: Eur J Cancer
  doi: 10.1016/S0959-8049(00)00436-6
  contributor:
    fullname: Perez
– volume: 21
  start-page: 761
  year: 2009
  ident: 10.1002/pros.23007-BIB0060|pros23007-cit-0060
  article-title: Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone
  publication-title: Oncol Rep
  contributor:
    fullname: Richert
– volume: 30
  start-page: 35
  year: 2012
  ident: 10.1002/pros.23007-BIB0058|pros23007-cit-0058
  article-title: Differential effects of TGF-β1 and FGF-2 on SDF-1α expression in human periodontal ligament cells derived from deciduous teeth in vitro
  publication-title: Int J Mol Med
  contributor:
    fullname: Hasegawa
– volume: 42
  start-page: 2116
  year: 2013
  ident: 10.1002/pros.23007-BIB0045|pros23007-cit-0045
  article-title: Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2013.1892
  contributor:
    fullname: Gravina
– volume: 30
  start-page: 674
  year: 2013
  ident: 10.1002/pros.23007-BIB0068|pros23007-cit-0068
  article-title: Androgen receptor in human prostate cancer-associated fibroblasts promotes prostate cancer epithelial cell growth and invasion
  publication-title: Med Oncol
  doi: 10.1007/s12032-013-0674-9
  contributor:
    fullname: Yu
– volume: 28
  start-page: 2043
  year: 2012
  ident: 10.1002/pros.23007-BIB0024|pros23007-cit-0024
  article-title: Silencing of CXCR4 by RNA interference inhibits cell growth and metastasis in human renal cancer cells
  publication-title: Oncol Rep
  doi: 10.3892/or.2012.2028
  contributor:
    fullname: Wang
– volume: 70
  start-page: 1066
  year: 2010
  ident: 10.1002/pros.23007-BIB0035|pros23007-cit-0035
  article-title: Effects of transplantation of adipose tissue-derived stem cells on prostate tumour
  publication-title: Prostate
  doi: 10.1002/pros.21140
  contributor:
    fullname: Lin
– volume: 67
  start-page: 61
  year: 2007
  ident: 10.1002/pros.23007-BIB0022|pros23007-cit-0022
  article-title: Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells
  publication-title: Prostate
  doi: 10.1002/pros.20500
  contributor:
    fullname: Sun
– volume: 7
  start-page: 46
  year: 2014
  ident: 10.1002/pros.23007-BIB0046|pros23007-cit-0046
  article-title: XPO1/CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa)
  publication-title: J Hematol Oncol
  doi: 10.1186/1756-8722-7-46
  contributor:
    fullname: Gravina
– volume: 66
  start-page: 32
  year: 2006
  ident: 10.1002/pros.23007-BIB0020|pros23007-cit-0020
  article-title: CXCL12/CXCR4 signalling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12
  publication-title: Prostate
  doi: 10.1002/pros.20318
  contributor:
    fullname: Chinni
– volume: 119
  start-page: 3917
  issue: 17
  year: 2012
  ident: 10.1002/pros.23007-BIB0027|pros23007-cit-0027
  article-title: A phase I/II study of chemosensitisation with the CXCR4 antagonist plerixafor in relapsed or refractory AML
  publication-title: Blood
  doi: 10.1182/blood-2011-10-383406
  contributor:
    fullname: Uy
– volume: 11
  start-page: 17
  year: 1999
  ident: 10.1002/pros.23007-BIB0007|pros23007-cit-0007
  article-title: Osteoblasts modulate secretion of urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) in human prostate cancer cells promoting migration and matrigel invasion
  publication-title: Oncol Res
  contributor:
    fullname: Festuccia
– volume: 8
  start-page: 290
  year: 2006
  ident: 10.1002/pros.23007-BIB0021|pros23007-cit-0021
  article-title: CXCR4 chemokine receptor mediates prostate tumour cell adhesion through alpha5 and beta3 integrins
  publication-title: Neoplasia
  doi: 10.1593/neo.05694
  contributor:
    fullname: Engl
– volume: 47
  start-page: 2353
  year: 2011
  ident: 10.1002/pros.23007-BIB0025|pros23007-cit-0025
  article-title: RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously downregulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2011.05.006
  contributor:
    fullname: Feng
– volume: 42
  start-page: 2838
  year: 2006
  ident: 10.1002/pros.23007-BIB0048|pros23007-cit-0048
  article-title: Pyrazolo[3,4-d]pyrimidines c-Src inhibitors reduce epidermal growth factor-induced migration in prostate cancer cells
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2006.06.024
  contributor:
    fullname: Angelucci
– volume: 18
  start-page: 385
  year: 2011
  ident: 10.1002/pros.23007-BIB0052|pros23007-cit-0052
  article-title: The TORC1/TORC2 inhibitor, Palomid 529, reduces tumour growth and sensitises to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells
  publication-title: Endocr Relat Cancer
  doi: 10.1530/ERC-11-0045
  contributor:
    fullname: Gravina
– volume: 18
  start-page: 4440
  year: 2011
  ident: 10.1002/pros.23007-BIB0004|pros23007-cit-0004
  article-title: Clinical trial update and novel therapeutic approaches for metastatic prostate cancer
  publication-title: Curr Med Chem
  doi: 10.2174/092986711797287539
  contributor:
    fullname: Larsson
– volume: 4
  start-page: 291
  year: 2004
  ident: 10.1002/pros.23007-BIB0013|pros23007-cit-0013
  article-title: The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis
  publication-title: J Exp Ther Oncol
  contributor:
    fullname: Arya
– volume: 103
  start-page: 700
  year: 2012
  ident: 10.1002/pros.23007-BIB0023|pros23007-cit-0023
  article-title: Thromboxane A2 receptor signalling facilitates tumour colonisation through P-selectin-mediated interaction of tumour cells with platelets and endothelial cells
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2012.02200.x
  contributor:
    fullname: Matsui
– volume: 14
  start-page: 709
  year: 2012
  ident: 10.1002/pros.23007-BIB0028|pros23007-cit-0028
  article-title: CXCR4 inhibition with AMD3100 sensitises prostate cancer to docetaxel chemotherapy
  publication-title: Neoplasia
  doi: 10.1593/neo.12324
  contributor:
    fullname: Domanska
– volume: 155
  start-page: 231
  year: 2009
  ident: 10.1002/pros.23007-BIB0030|pros23007-cit-0030
  article-title: A CXCR4 antagonist CTCE-9908 inhibits primary tumour growth and metastasis of breast cancer
  publication-title: J Surg Res
  doi: 10.1016/j.jss.2008.06.044
  contributor:
    fullname: Huang
– volume: 64
  start-page: 8604
  year: 2004
  ident: 10.1002/pros.23007-BIB0011|pros23007-cit-0011
  article-title: CXCR4 regulates growth of both primary and metastatic breast cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-1844
  contributor:
    fullname: Smith
– volume: 91
  start-page: 902
  year: 2012
  ident: 10.1002/pros.23007-BIB0006|pros23007-cit-0006
  article-title: Pathological roles of invadopodia in cancer invasion and metastasis
  publication-title: Eur J Cell Biol
  doi: 10.1016/j.ejcb.2012.04.005
  contributor:
    fullname: Yamaguchi
– volume: 6
  start-page: 424
  year: 2012
  ident: 10.1002/pros.23007-BIB0005|pros23007-cit-0005
  article-title: Occupy tissue: The movement in cancer metastasis
  publication-title: Cell Adh Migr
  doi: 10.4161/cam.21559
  contributor:
    fullname: Bradbury
– volume: 70
  start-page: 9650
  year: 2010
  ident: 10.1002/pros.23007-BIB0059|pros23007-cit-0059
  article-title: P53 status in stromal fibroblasts modulates tumour growth in an SDF1-dependent manner
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-1146
  contributor:
    fullname: Addadi
– volume: 155
  start-page: 231
  year: 2009
  ident: 10.1002/pros.23007-BIB0064|pros23007-cit-0064
  article-title: A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer
  publication-title: J Surg Res
  doi: 10.1016/j.jss.2008.06.044
  contributor:
    fullname: Huang
– volume: 69
  start-page: 1460
  year: 2009
  ident: 10.1002/pros.23007-BIB0065|pros23007-cit-0065
  article-title: Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth
  publication-title: Prostate
  doi: 10.1002/pros.21008
  contributor:
    fullname: Porvasnik
– volume: 182
  start-page: 250
  year: 2013
  ident: 10.1002/pros.23007-BIB0029|pros23007-cit-0029
  article-title: Effective inhibition of metastases and primary tumour growth with CTCE-9908 in oesophageal cancer
  publication-title: J Surg Res
  doi: 10.1016/j.jss.2012.09.035
  contributor:
    fullname: Drenckhan
SSID ssj0010002
Score 4.330188
SourceID crossref
SourceType Aggregation Database
StartPage 1227
Subtitle CXCR4 Inhibition Has Anti-Tumor and Anti-Metastatic Effects in Prostate Cancer Models
Title CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models
Volume 75
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1dS-tAEF1qBfHlcvUqeq_KgD4Zok2aJuZR6hdiRcQrfSvZJNWAN5U2Eewf8g_cH-jMbLKJHw_Vl1C23U2zc5iZzZ45K8RO7Es_Gno-LkucwHRcaZkHkeWbEn0h7crZVkyFwr1L9-yvc97v9BuN_zXWUp7JvXD6aV3Jd6yKbWhXqpL9gmX1oNiAn9G-eEUL43UmG3f73WvHeCzUp5UPS9L7RDIPyxiTLGs8MeQoVZsEE_S5RsZTTUdHB1RNlISG5FIGSkQDZndwBVX-bzQ27nCRXtS-cQNJd2KHx1FGJCO-GzG8uCqJ-GNhPCbVAV1uyefsTOoJMMHyquhRcX-Cp0TVpp0SNzZNE-MirzhEPdIE4aOnFP-y-iKfJioNHj3oxlsOozyaHqR4rWF1NAW29H621zIxwnp1V60OWSkhadccr2UriYEiiGPW4n4aIJTgLM0MUeBbXhUGy63_d9FRcxaVvrM9oL4D7jsn5m3P7xCR9Ohai5bRhgnvXZUPoEVx7f3qvrU0qJbP3PwUP4qFCBwqVC2JRpwui4VeQbX4JV4YXPAGXFCBCwpwAYELECBA4AIFLqjABQpcIJ9BgwsYS6DAxX1r4AINLrwblOACBS6ogQsUuFbE7snxTffMLB8Up44FVAYfp7K9Kpop_t81AXan7UXD0MLA23KkjCSuSULPDSP3IAqGkbsutmcY8PdMv_ojFivsbYhmNs7jTUwyM7nFNn0F0_uPDg
link.rule.ids 315,786,790,27955,27956
linkProvider Wiley-Blackwell
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CXCR4+pharmacogical+inhibition+reduces+bone+and+soft+tissue+metastatic+burden+by+affecting+tumor+growth+and+tumorigenic+potential+in+prostate+cancer+preclinical+models&rft.jtitle=The+Prostate&rft.au=Gravina%2C+Giovanni+Luca&rft.au=Mancini%2C+Andrea&rft.au=Muzi%2C+Paola&rft.au=Ventura%2C+Luca&rft.date=2015-07-01&rft.issn=0270-4137&rft.volume=75&rft.issue=12&rft.spage=1227&rft.epage=1246&rft_id=info:doi/10.1002%2Fpros.23007&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_pros_23007
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-4137&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-4137&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-4137&client=summon