Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways Saberi, Ybanez, et al

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Published inHepatology (Baltimore, Md.) Vol. 59; no. 4; pp. 1543 - 1554
Main Authors Saberi, Behnam, Ybanez, Maria D., Johnson, Heather S., Gaarde, William A., Han, Derick, Kaplowitz, Neil
Format Journal Article
LanguageEnglish
Published 01.04.2014
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Author Kaplowitz, Neil
Gaarde, William A.
Saberi, Behnam
Ybanez, Maria D.
Johnson, Heather S.
Han, Derick
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Cites_doi 10.1074/jbc.273.37.23758
10.1124/mol.112.079863
10.1016/S0891-5849(00)00429-9
10.1016/0925-4439(95)00124-7
10.1002/hep.24690
10.1083/jcb.117.1.121
10.4161/auto.4240
10.1016/j.bcp.2006.06.032
10.1074/jbc.M109.054999
10.1007/BF00318364
10.3748/wjg.v16.i30.3731
10.1074/jbc.M708916200
10.1053/j.gastro.2008.07.006
10.1053/j.gastro.2006.03.045
10.1007/978-3-642-00663-0_10
10.1523/JNEUROSCI.21-09-02929.2001
10.1042/bj3530411
10.1053/jhep.2001.29197
10.1152/ajpcell.90654.2007
10.1038/nature09571
10.1074/jbc.M511178200
10.1161/01.RES.0000256090.42690.05
10.1016/j.bcp.2009.12.011
10.1007/s00535-011-0500-0
10.1124/mol.109.058479
10.1074/jbc.M404170200
10.1002/hep.22177
10.1074/jbc.M111.276089
10.1038/nrm2847
10.1074/jbc.M106083200
10.1093/cvr/cvp166
10.1042/bj3510095
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References Davies (10.1002/hep.26625-BIB0030|hep26625-cit-0030) 2000; 351
Han (10.1002/hep.26625-BIB0028|hep26625-cit-0028) 2001; 353
Xie (10.1002/hep.26625-BIB0016|hep26625-cit-0016) 2006; 281
Hanawa (10.1002/hep.26625-BIB0003|hep26625-cit-0003) 2008; 283
Rosse (10.1002/hep.26625-BIB0010|hep26625-cit-0010) 2010; 11
Han (10.1002/hep.26625-BIB0004|hep26625-cit-0004) 2010
Towler (10.1002/hep.26625-BIB0018|hep26625-cit-0018) 2007; 100
Choi (10.1002/hep.26625-BIB0022|hep26625-cit-0022) 2010; 79
Lee (10.1002/hep.26625-BIB0001|hep26625-cit-0001) 2008; 47
Maher (10.1002/hep.26625-BIB0015|hep26625-cit-0015) 2001; 21
Nakagawa (10.1002/hep.26625-BIB0007|hep26625-cit-0007) 2008; 135
Wang (10.1002/hep.26625-BIB0029|hep26625-cit-0029) 2006; 72
Hoyer-Hansen (10.1002/hep.26625-BIB0024|hep26625-cit-0024) 2007; 3
Saberi (10.1002/hep.26625-BIB0009|hep26625-cit-0009) 2008; 295
Ni (10.1002/hep.26625-BIB0026|hep26625-cit-0026) 2012; 55
Igusa (10.1002/hep.26625-BIB0027|hep26625-cit-0027) 2012; 47
Croquet (10.1002/hep.26625-BIB0013|hep26625-cit-0013) 1996; 1315
Win (10.1002/hep.26625-BIB0005|hep26625-cit-0005) 2011; 286
Wetsel (10.1002/hep.26625-BIB0012|hep26625-cit-0012) 1992; 117
Samari (10.1002/hep.26625-BIB0023|hep26625-cit-0023) 1998; 273
Peralta (10.1002/hep.26625-BIB0020|hep26625-cit-0020) 2001; 34
Nakada (10.1002/hep.26625-BIB0019|hep26625-cit-0019) 2010; 468
Sharma (10.1002/hep.26625-BIB0008|hep26625-cit-0008) 2012; 82
Kewalramani (10.1002/hep.26625-BIB0025|hep26625-cit-0025) 2009; 84
Bareggi (10.1002/hep.26625-BIB0011|hep26625-cit-0011) 1995; 280
Shinohara (10.1002/hep.26625-BIB0006|hep26625-cit-0006) 2010; 285
Shin (10.1002/hep.26625-BIB0021|hep26625-cit-0021) 2009; 76
Wang (10.1002/hep.26625-BIB0031|hep26625-cit-0031) 2004; 279
Gunawan (10.1002/hep.26625-BIB0002|hep26625-cit-0002) 2006; 131
Domenicotti (10.1002/hep.26625-BIB0014|hep26625-cit-0014) 2000; 29
Yang (10.1002/hep.26625-BIB0017|hep26625-cit-0017) 2010; 16
Brändlin (10.1002/hep.26625-BIB0032|hep26625-cit-0032) 2002; 277
References_xml – volume: 273
  start-page: 23758
  year: 1998
  ident: 10.1002/hep.26625-BIB0023|hep26625-cit-0023
  article-title: Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.37.23758
  contributor:
    fullname: Samari
– volume: 82
  start-page: 1001
  year: 2012
  ident: 10.1002/hep.26625-BIB0008|hep26625-cit-0008
  article-title: Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.112.079863
  contributor:
    fullname: Sharma
– volume: 29
  start-page: 1280
  year: 2000
  ident: 10.1002/hep.26625-BIB0014|hep26625-cit-0014
  article-title: Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding
  publication-title: Free Radic Biol Med
  doi: 10.1016/S0891-5849(00)00429-9
  contributor:
    fullname: Domenicotti
– volume: 1315
  start-page: 163
  year: 1996
  ident: 10.1002/hep.26625-BIB0013|hep26625-cit-0013
  article-title: Five isoenzymes of protein kinase C are expressed in normal and STZ-diabetic rat hepatocytes: effect of phorbol 12-myristate 13-acetate
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0925-4439(95)00124-7
  contributor:
    fullname: Croquet
– volume: 55
  start-page: 222
  year: 2012
  ident: 10.1002/hep.26625-BIB0026|hep26625-cit-0026
  article-title: Activation of autophagy protects against acetaminophen-induced hepatotoxicity
  publication-title: Hepatology
  doi: 10.1002/hep.24690
  contributor:
    fullname: Ni
– volume: 117
  start-page: 121
  year: 1992
  ident: 10.1002/hep.26625-BIB0012|hep26625-cit-0012
  article-title: Tissue and cellular distribution of the extended family of protein kinase C isoenzymes
  publication-title: J Cell Biol
  doi: 10.1083/jcb.117.1.121
  contributor:
    fullname: Wetsel
– volume: 3
  start-page: 381
  year: 2007
  ident: 10.1002/hep.26625-BIB0024|hep26625-cit-0024
  article-title: AMP-activated protein kinase: a universal regulator of autophagy?
  publication-title: Autophagy
  doi: 10.4161/auto.4240
  contributor:
    fullname: Hoyer-Hansen
– volume: 72
  start-page: 881
  year: 2006
  ident: 10.1002/hep.26625-BIB0029|hep26625-cit-0029
  article-title: Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytes
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2006.06.032
  contributor:
    fullname: Wang
– volume: 285
  start-page: 8244
  year: 2010
  ident: 10.1002/hep.26625-BIB0006|hep26625-cit-0006
  article-title: Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.054999
  contributor:
    fullname: Shinohara
– volume: 280
  start-page: 617
  year: 1995
  ident: 10.1002/hep.26625-BIB0011|hep26625-cit-0011
  article-title: Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study
  publication-title: Cell Tissue Res
  doi: 10.1007/BF00318364
  contributor:
    fullname: Bareggi
– volume: 16
  start-page: 3731
  year: 2010
  ident: 10.1002/hep.26625-BIB0017|hep26625-cit-0017
  article-title: AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v16.i30.3731
  contributor:
    fullname: Yang
– volume: 283
  start-page: 13565
  year: 2008
  ident: 10.1002/hep.26625-BIB0003|hep26625-cit-0003
  article-title: Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M708916200
  contributor:
    fullname: Hanawa
– volume: 135
  start-page: 1311
  year: 2008
  ident: 10.1002/hep.26625-BIB0007|hep26625-cit-0007
  article-title: Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.07.006
  contributor:
    fullname: Nakagawa
– volume: 131
  start-page: 165
  year: 2006
  ident: 10.1002/hep.26625-BIB0002|hep26625-cit-0002
  article-title: c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.03.045
  contributor:
    fullname: Gunawan
– start-page: 267
  year: 2010
  ident: 10.1002/hep.26625-BIB0004|hep26625-cit-0004
  article-title: Signal transduction pathways involved in drug-induced liver injury
  publication-title: Handb Exp Pharmacol
  doi: 10.1007/978-3-642-00663-0_10
  contributor:
    fullname: Han
– volume: 21
  start-page: 2929
  year: 2001
  ident: 10.1002/hep.26625-BIB0015|hep26625-cit-0015
  article-title: How protein kinase C activation protects nerve cells from oxidative stress-induced cell death
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-09-02929.2001
  contributor:
    fullname: Maher
– volume: 353
  start-page: 411
  year: 2001
  ident: 10.1002/hep.26625-BIB0028|hep26625-cit-0028
  article-title: Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space
  publication-title: Biochem J
  doi: 10.1042/bj3530411
  contributor:
    fullname: Han
– volume: 34
  start-page: 1164
  year: 2001
  ident: 10.1002/hep.26625-BIB0020|hep26625-cit-0020
  article-title: Adenosine monophosphate-activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemia-reperfusion injury in the rat
  publication-title: Hepatology
  doi: 10.1053/jhep.2001.29197
  contributor:
    fullname: Peralta
– volume: 295
  start-page: C50
  year: 2008
  ident: 10.1002/hep.26625-BIB0009|hep26625-cit-0009
  article-title: Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.90654.2007
  contributor:
    fullname: Saberi
– volume: 468
  start-page: 653
  year: 2010
  ident: 10.1002/hep.26625-BIB0019|hep26625-cit-0019
  article-title: Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
  publication-title: Nature
  doi: 10.1038/nature09571
  contributor:
    fullname: Nakada
– volume: 281
  start-page: 6366
  year: 2006
  ident: 10.1002/hep.26625-BIB0016|hep26625-cit-0016
  article-title: Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M511178200
  contributor:
    fullname: Xie
– volume: 100
  start-page: 328
  year: 2007
  ident: 10.1002/hep.26625-BIB0018|hep26625-cit-0018
  article-title: AMP-activated protein kinase in metabolic control and insulin signaling
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000256090.42690.05
  contributor:
    fullname: Towler
– volume: 79
  start-page: 1352
  year: 2010
  ident: 10.1002/hep.26625-BIB0022|hep26625-cit-0022
  article-title: AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2009.12.011
  contributor:
    fullname: Choi
– volume: 47
  start-page: 433
  year: 2012
  ident: 10.1002/hep.26625-BIB0027|hep26625-cit-0027
  article-title: Loss of autophagy promotes murine acetaminophen hepatotoxicity
  publication-title: J Gastroenterol
  doi: 10.1007/s00535-011-0500-0
  contributor:
    fullname: Igusa
– volume: 76
  start-page: 884
  year: 2009
  ident: 10.1002/hep.26625-BIB0021|hep26625-cit-0021
  article-title: Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.109.058479
  contributor:
    fullname: Shin
– volume: 279
  start-page: 31089
  year: 2004
  ident: 10.1002/hep.26625-BIB0031|hep26625-cit-0031
  article-title: Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M404170200
  contributor:
    fullname: Wang
– volume: 47
  start-page: 1401
  year: 2008
  ident: 10.1002/hep.26625-BIB0001|hep26625-cit-0001
  article-title: Acute liver failure: summary of a workshop
  publication-title: Hepatology
  doi: 10.1002/hep.22177
  contributor:
    fullname: Lee
– volume: 286
  start-page: 35071
  year: 2011
  ident: 10.1002/hep.26625-BIB0005|hep26625-cit-0005
  article-title: c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.276089
  contributor:
    fullname: Win
– volume: 11
  start-page: 103
  year: 2010
  ident: 10.1002/hep.26625-BIB0010|hep26625-cit-0010
  article-title: PKC and the control of localized signal dynamics
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2847
  contributor:
    fullname: Rosse
– volume: 277
  start-page: 6490
  year: 2002
  ident: 10.1002/hep.26625-BIB0032|hep26625-cit-0032
  article-title: Protein kinase C (PKC)eta-mediated PKC mu activation modulates ERK and JNK signal pathways
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M106083200
  contributor:
    fullname: Brändlin
– volume: 84
  start-page: 42
  year: 2009
  ident: 10.1002/hep.26625-BIB0025|hep26625-cit-0025
  article-title: AMP-activated protein kinase confers protection against TNF-{alpha}-induced cardiac cell death
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvp166
  contributor:
    fullname: Kewalramani
– volume: 351
  start-page: 95
  year: 2000
  ident: 10.1002/hep.26625-BIB0030|hep26625-cit-0030
  article-title: Specificity and mechanism of action of some commonly used protein kinase inhibitors
  publication-title: Biochem J
  doi: 10.1042/bj3510095
  contributor:
    fullname: Davies
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Subtitle Saberi, Ybanez, et al
Title Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways
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