Electrochemical Carboarylation of Activated Alkenes with CO 2 and Electron‐deficient Aryl Bromides

Comprehensive Summary The simultaneous construction of two vicinal C—C bonds in a molecule remains a significant challenge. In this work, we disclose an electroreductive carboarylation of activated alkenes under mild, transition metal‐free conditions. Utilizing readily available starting materials (...

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Bibliographic Details
Published inChinese journal of chemistry
Main Authors Yang, Zhaoliang, Liu, Chunlei, Zhong, Cheng, Zhang, Jianye, Liu, Shengzhang, Yu, mingming, Li, yangyang, Yi, Hong, Lei, Aiwen
Format Journal Article
LanguageEnglish
Published 10.09.2024
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Summary:Comprehensive Summary The simultaneous construction of two vicinal C—C bonds in a molecule remains a significant challenge. In this work, we disclose an electroreductive carboarylation of activated alkenes under mild, transition metal‐free conditions. Utilizing readily available starting materials (electron‐deficient aryl bromides, activated alkenes, and CO 2 ), this method demonstrates broad substrate scope and good functional group tolerance. Notably, this strategy enables the addition of two distinct electrophiles across an alkene in a highly chemo‐ and regioselective manner.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202400661