Effect of osmolytes on the binding of EGR 1 transcription factor to DNA

• Published in: Biopolymers Vol. 103; no. 2; pp. 74 - 87
• Main Authors: Mikles, David C., Bhat, Vikas, Schuchardt, Brett J., McDonald, Caleb B., Farooq, Amjad
• Format: Journal Article
• Language: English
• Published: 01.02.2015
• ISSN: 0006-3525; 1097-0282
• DOI: 10.1002/bip.22556

Osmolytes play a key role in maintaining protein stability and mediating macromolecular interactions within the intracellular environment of the cell. Herein, we show that osmolytes such as glycerol, sucrose, and polyethylene glycol 400 (PEG400) mitigate the binding of early growth response (protein...