Tau‐induced brain atrophy and neuroinflammation accelerated by low‐protein diet and decelerated by selected essential amino acids in a murine model of tauopathies Molecular and cell biology/neurodegeneration and neuroprotection

• Published in: Alzheimer's & dementia Vol. 16; no. S2
• Main Authors: Takado, Yuhei, Sato, Hideaki, Tsukamoto‐Yasui, Masako, Minatohara, Keiichiro, Takahashi, Manami, Urushihata, Takuya, Takuwa, Hiroyuki, Ono, Maiko, Maeda, Jun, Sahara, Naruhiko, Aoki, Ichio, Toyoda, Sakiko, Karakawa, Sachise, Isokawa, Muneki, Kawasaki, Noriko, Ueno, Satoko, Kanda, Mayuka, Nishimura, Mai, Suzuki, Katsuya, Mitsui, Akira, Nagao, Kenji, Higuchi, Makoto, Kitamura, Akihiko
• Format: Journal Article
• Language: English
• Published: 01.12.2020

Abstract Background Nutritional epidemiology has implicated dietary protein intake in senile dementias. However, mechanistic links of protein and amino acids to age‐related neurodegenerative conditions remain unclear. Here, we tested the hypothesis that dietary intake of protein and amino acids coul...