Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-（1-hydroxypentyl）-benzoate, in rats and dogs

• Published in: 中国药理学报：英文版 Vol. 39; no. 2; pp. 275 - 285
• Main Author: Jiang LI;Shao-feng XU;Ying PENG;Nan FENG;Ling WANG;Xiao-liang WANG
• Format: Journal Article
• Language: English
• Published: 2018
• Subjects: 老鼠;小说;侧面;狗;钾;vivo;安息香酸盐;排泄物

Potassium 2-（1-hydroxypentyl）-benzoate （d/-PHPB） is a novel pro-drug of 3-n-butylphthalide （dkNBP） that is used to treat ischemic stroke. Currently, dl-PHPB is in phase II-III clinical trials in China. In this study, we investigated the conversion and pharmacokinetics profiles of dI-PHPB in vitro an...