miRNA调控脂肪干细胞分化的研究进展

目的总结近年来miRNA在调控脂肪干细胞（adipose-derived stem cells, ADSCs）分化中的研究进展。方法查阅近年来与miRNA和ADSCs分化调控相关的文献，详细分析其调节机制，并进行综述。结果在ADSCs分化过程中，miRNA的表达会改变，并且miRNA可通过调节细胞分化相关的信号通路，调控ADSCs定向分化为脂肪细胞、成骨细胞、软骨细胞、神经细胞、肝细胞等。结论利用miRNA对ADSCs分化的调控作用，构建出符合需求的组织工程种子细胞，用于临床分子靶向治疗和干细胞治疗。...

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Bibliographic Details
Published in中国修复重建外科杂志 Vol. 31; no. 12; pp. 1506 - 1511
Main Author 周兰庭;冯雁婷;戴景兴;欧阳钧
Format Journal Article
LanguageChinese
Published 2017
Subjects
miRNA
多向分化
脂肪干细胞
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Summary:目的总结近年来miRNA在调控脂肪干细胞（adipose-derived stem cells, ADSCs）分化中的研究进展。方法查阅近年来与miRNA和ADSCs分化调控相关的文献，详细分析其调节机制，并进行综述。结果在ADSCs分化过程中，miRNA的表达会改变，并且miRNA可通过调节细胞分化相关的信号通路，调控ADSCs定向分化为脂肪细胞、成骨细胞、软骨细胞、神经细胞、肝细胞等。结论利用miRNA对ADSCs分化的调控作用，构建出符合需求的组织工程种子细胞，用于临床分子靶向治疗和干细胞治疗。
Bibliography:51-1372/R
ZHOU Lanting1, 2, FENG Yanting2, DAI Jingxing2, OUYANG Jun2（1. Medical College, Hubei University of Arts and Science, Xiangyang Hubei, 441053, P.R.China 2. Department of Anatomy, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China）
Objective To review the research progress of miRNA regulation in the differentiation of adipose- derived stem cells （ADSCs）. Methods The recent literature associated with miRNAs and differentiation of ADSCs was reviewed. The regulatory mechanism was analyzed in detail and summarized. Results The results indicate that the expression of miRNAs changes during differentiation of ADSCs. In addition, miRNAs regulate the differentiation of ADSCs into adipocytes, osteoblasts, chondrocytes, neurons, and hepatocytes by regulating the signaling pathways involved in cell differentiation. Conclusion Through controlling the differentiation of ADSCs by miRNAs, the suitable seed cell for tissue engineering can be established. The review will provide a theoretical basis for
ISSN:1002-1892