针灸调控炎症通路相关研究的回顾

目的：分析近十年来针灸通过调控炎症信号通路治疗炎性疾病的研究，阐述其可能机制，为针灸治疗炎症性疾病提供理论指导。方法：查阅PubMed上国内外针灸调控酪氨酸激酶一信号转导子和转录激活子（Janus protein-tyrosine kinase／signaltransducerandactivator of transcription，JAK-STAT），核转录因子kappaB（nuclear factor kappa B，NF-KB）和丝裂原活化蛋白激酶（mitogen-activated proteinkinase，MAPK）这三条炎症信号通路治疗炎症性疾病的，临床和实验研究，分析其对这三...

Full description

Saved in:
Bibliographic Details
Published in世界针灸杂志：英文版 no. 2; pp. 63 - 69
Main Author 舒晴 陈丽 何文娟 周焕娇 梁凤霞
Format Journal Article
LanguageEnglish
Published 2016
Subjects
JAK—STAT
MAPK
NF-KB
炎症
针灸
Online AccessGet full text
ISSN1003-5257

Cover

More Information
Summary:目的：分析近十年来针灸通过调控炎症信号通路治疗炎性疾病的研究，阐述其可能机制，为针灸治疗炎症性疾病提供理论指导。方法：查阅PubMed上国内外针灸调控酪氨酸激酶一信号转导子和转录激活子（Janus protein-tyrosine kinase／signaltransducerandactivator of transcription，JAK-STAT），核转录因子kappaB（nuclear factor kappa B，NF-KB）和丝裂原活化蛋白激酶（mitogen-activated proteinkinase，MAPK）这三条炎症信号通路治疗炎症性疾病的，临床和实验研究，分析其对这三个炎症信号通路中细胞因子的影响，并进行系统归纳。结果：针灸能导致IAK—STAT、NF-KB、MAPK这三条炎症信号通路的上下游细胞因子的表达下降，对这三条通路有明显的抑制作用。结论：针灸能通过抑制炎症信号通路的方式达到抗炎的作用，抗炎作用可能是针灸效应机制的重要组成部分。
Bibliography:11-2892/R
Objective To analyses the studies about acupuncture regulating inflammatory signaling pathway in treatment of inflammation- related diseases, which can explain the possible mechanism and provide evidence of acupuncture in treatment of inflammatory diseases. Methods Acupuncture-related studies of animal experiments and clinical trials in PubMed about three signaling pathway, Janus protein-tyrosine kinase/signal transducer and activator of transcription （JAK-STAT）, nuclear factor kappa B （NF-KB） and mitogen-act-ivated protein kinase （MAPK） were retrieved. The effective of acupuncture on cytokines of the three signaling pathway were analyzed and systematical（y summarized. Results Acupuncture can inhibit the activity of JAK-STAT, NF-KB and MAPK inflammatory signaling pathway by down-regulate the cytokines of them. Conclusion Acupuncture and moxibustion have the function of anti-inflammation though inhibiting the JAK-STAT, NF-KB and MAPK signaling pathway. Anti-inflammation maybe plays a vital role in the mechanism of acupuncture and moxibustion.
SHU Qing , CHEN Li , LIANG Feng-xia HE Wen-juan , ZHOU Huan-jiao（ 1. Acupuncture-moxibustion and Othopaedic College, Hubei University of Chinese Medicine, Wuhan 430061, China; 2. Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture ＆ Moxibustion, Wuhan 430061, Hubei Province, China）
acupuncture; inflammation; JAK-STAT; NF-KB; MAPK
ISSN:1003-5257