Effect of Huanshuai Recipe Oral Liquid （缓衰口服液） on Renal Dysfunction Progression in Patients with Atherosclerotic Renal Artery Stenosis
Objective： To investigate the effect of Huanshuai Recipe Oral Liquid （缓衰口服液, HSR） on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis （ARAS）. Methods： A total of 52 ARAS patients with the Chinese medicine （CM） syndrome of qi deficiency and blood s...
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| Published in | 中国结合医学杂志：英文版 no. 11; pp. 811 - 816 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
2015
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Objective： To investigate the effect of Huanshuai Recipe Oral Liquid （缓衰口服液, HSR） on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis （ARAS）. Methods： A total of 52 ARAS patients with the Chinese medicine （CM） syndrome of qi deficiency and blood stasis, phlegm and dampness retention were recruited and randomly assigned into the treatment group （36 cases） and the control group （16 cases）. Both groups received a basic treatment （high-quality low-protein diet, blood pressure control, lipid-lowering, correcting the acidosis, etc.）. In addition, the treatment group received 20 mL HSR and the control group received placebo, 3 times a day for 6 months. Renal function （serum creatinine, blood urea nitrogen and uric acid） and blood lipids （cholesterol, triglycerides and low density lipoprotein） were examined monthly. The estimated glomerular filtration rate （eGFR） and CM syndrome score were compared between groups. Results： After treatment, compared with the control group, the serum creatinine level, uric acid level and CM syndrome score of the treatment group were significantly decreased （P〈0.05 or P〈0.01）, and the eGFR in the treatment group were significantly increased （P〈0.05）. Conclusion： HSR can effectively improve the renal function and clinical symptoms of ARAS patients. |
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| Bibliography: | WANG Xiu-juan,RAO Xiang-rong, LI Shen,WANG Li , LIU Chang , ZHANG Gai-hua , HAN Dong-yan ,ZHAO Yu ,ZHANG Nan-nan, LI Xue-xia,CHEN Shuai （1. Department of Nephropathy, Guang＇anmen Hospital, China Academy of Chinese Medical Sciences, Beijing （100053）, China; 2. Department of Nephropathy, Beijing Fangshan Hospital of Traditional Chinese Medicine, Beijing （102400）, China; 3. Department of Nephropathy, The Second People＇s Hospital of Zhuhai, Zhuhai, Guangdong Province （519000）, China; 4. Department of Nephropathy, Beijing Miyun Hospital of Traditional Chinese Medicine, Beijing （101500）, China） 11-4928/R atherosclerotic renal artery stenosis, Huanshuai Recipe Oral Liquid, renal dysfunction, Chinese medicine Objective： To investigate the effect of Huanshuai Recipe Oral Liquid （缓衰口服液, HSR） on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis （ARAS）. Methods： A total of 52 ARAS patients with the Chinese medicine （CM） syndrome of qi deficiency and blood stasis, phlegm and dampness retention were recruited and randomly assigned into the treatment group （36 cases） and the control group （16 cases）. Both groups received a basic treatment （high-quality low-protein diet, blood pressure control, lipid-lowering, correcting the acidosis, etc.）. In addition, the treatment group received 20 mL HSR and the control group received placebo, 3 times a day for 6 months. Renal function （serum creatinine, blood urea nitrogen and uric acid） and blood lipids （cholesterol, triglycerides and low density lipoprotein） were examined monthly. The estimated glomerular filtration rate （eGFR） and CM syndrome score were compared between groups. Results： After treatment, compared with the control group, the serum creatinine level, uric acid level and CM syndrome score of the treatment group were significantly decreased （P〈0.05 or P〈0.01）, and the eGFR in the treatment group were significantly increased （P〈0.05）. Conclusion： HSR can effectively improve the renal function and clinical symptoms of ARAS patients. |
| ISSN: | 1672-0415 1993-0402 |