miR-27b synergizes with anticancer drugs via p53 activation and CYPIB1 suppression

• Published in: 细胞研究：英文版 no. 4; pp. 477 - 495
• Main Author: Wenjing Mu Chaobo Hu Haibin Zhang Zengqiang Qu Jin Cen Zhixin Qiu Chao Li Haozhen Ren Yixue Li Xianghuo He Xiaolei Shi Lijian Hui
• Format: Journal Article
• Language: English
• Published: 2015
• Subjects: miRNA; p53基因; 协同作用; 微RNA; 抗癌药物; 激活; 癌症患者; 癌症治疗

Liver and kidney cancers are notorious for drug resistance. Due to the complexity, redundancy and interpatient heterogeneity of resistance mechanisms, most efforts targeting a single pathway were unsuccessful. Novel personalized therapies targeting multiple essential drug resistance pathways in para...