Oncogenic Role of Skp2 and p27^Kip1 in Intraductal Proliferative Lesions of the Breast

• Published in: 中国医学科学杂志：英文版 Vol. 27; no. 3; pp. 161 - 166
• Main Author: Yan Lv Yun Niu Xiu-min Ding Xu-qi Xiao
• Format: Journal Article
• Language: English
• Published: 2012
• Subjects: p27; Skp2; 乳腺癌; 增生性; 病变; 石蜡包埋组织; 管内; 致癌作用

Objective To investigate whether the connection of p27^Kip1 to S-phase kinase-associated protein 2 （Skp2） plays an oncogenic role in intraductal proliferative lesions of the breast. Methods Here we investigated the mechanism involved in association of Skp2’s degradation of p27^Kip1 with the breast c...