（1S,2S）-1,2-二苯基乙二胺修饰Ir/SiO_2催化苯乙酮及其衍生物不对称加氢

不添加任何稳定剂,在碱性条件下制备了5%Ir/SiO2催化剂,并用于催化苯乙酮的不对称加氢反应中,详细考察了碱和手性修饰剂种类、氢气压力、反应温度、（1S,2S）-1,2-二苯基乙二胺（（1S,2S）-DPEN）浓度对反应的影响.在优化反应条件下,5%Ir/SiO2催化剂表现出较好的反应活性和对映选择性.其中,苯乙酮不对称加氢反应的对映选择性达70%.该催化剂不需要任何稳定剂,制备方法简单,催化性能稳定,通过简单的离心分离即可循环使用....

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Bibliographic Details
Published in催化学报 Vol. 33; no. 7; pp. 1154 - 1160
Main Author 杨朝芬 杨俊 孙晓东 朱艳琴 王齐 陈华
Format Journal Article
LanguageChinese
Published 2012
Subjects
多相不对称加氢
对映选择性
苯乙酮
铱
（1S,2S）-1,2-二苯基乙二胺
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ISSN0253-9837
1872-2067

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Summary:不添加任何稳定剂,在碱性条件下制备了5%Ir/SiO2催化剂,并用于催化苯乙酮的不对称加氢反应中,详细考察了碱和手性修饰剂种类、氢气压力、反应温度、（1S,2S）-1,2-二苯基乙二胺（（1S,2S）-DPEN）浓度对反应的影响.在优化反应条件下,5%Ir/SiO2催化剂表现出较好的反应活性和对映选择性.其中,苯乙酮不对称加氢反应的对映选择性达70%.该催化剂不需要任何稳定剂,制备方法简单,催化性能稳定,通过简单的离心分离即可循环使用.
Bibliography:YANG Chaofen1, YANG Jun1, SUN Xiaodong1, ZHU Yanqin1, WANG Qi1, CHEN Hua2,＊ 1Research Center for Analysis and Measurement, Kunming University of Science and Technology, Kunming 650093, Yunnan, China 2Key Laboratory of Green Chemistry and Technology, Ministry of Education, Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, China
iridium; acetophenone; heterogeneous asymmetric hydrogenation; （1S; 2S）-diphenylethylenediamine; enantioselectivity
An efficient and highly dispersed 5%Ir/SiO2 catalyst for the asymmetric hydrogenation of acetophenone and its derivatives were prepared under basic conditions without the use of any stabilizer. The effects of different reaction parameters, namely, catalyst preparation, base used, chiral modifier, and concentration of （1S,2S）-diphenylethylenediamine （（1S,2S）-DPEN）, were evaluated. Under optimum conditions with 5%Ir/SiO2 modified by （1S,2S）-DPEN, a high ee value of 70.0% was obtained for the asymmetric hydrogenation of aceto
ISSN:0253-9837
1872-2067