565例双侧原发性乳腺癌临床病理特征分析
目的探讨原发性双侧乳腺癌（bilateral primary breast cancer,BPBC）患者的临床病理特征。方法收集1971年1月—2011年11月间我院诊治的565例双乳癌患者临床资料。对比分析同时性双乳癌（bilateral synchronous breast cancer）和异时性双乳癌（bilateral asynchronous breast cancer）在发病年龄、发病间隔、月经情况、家族史、肿瘤体积、临床分期、淋巴结数目、激素受体等临床病理特征的差异。结果异时性双乳癌首发癌年龄要早于同时性双乳癌（P〈0.05）。同时性/异时性双乳癌在家族史、肿瘤体积、临床分期、腋...
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| Published in | 肿瘤防治研究 Vol. 39; no. 6; pp. 632 - 636 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
2012
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| Subjects | |
| Online Access | Get full text |
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| Abstract | 目的探讨原发性双侧乳腺癌（bilateral primary breast cancer,BPBC）患者的临床病理特征。方法收集1971年1月—2011年11月间我院诊治的565例双乳癌患者临床资料。对比分析同时性双乳癌（bilateral synchronous breast cancer）和异时性双乳癌（bilateral asynchronous breast cancer）在发病年龄、发病间隔、月经情况、家族史、肿瘤体积、临床分期、淋巴结数目、激素受体等临床病理特征的差异。结果异时性双乳癌首发癌年龄要早于同时性双乳癌（P〈0.05）。同时性/异时性双乳癌在家族史、肿瘤体积、临床分期、腋淋巴结数目方面的差异均无统计学意义（P〉0.05）。同时性双乳癌两侧病灶内分泌受体表达一致率高于异时性双乳癌（P〈0.01）。无论同时性或异时性双乳癌其第二癌的肿瘤体积、临床分期和腋淋巴结情况都优于第一癌。同时性双乳癌与异时性双乳癌5年无病生存率与10年总生存率之间的差异有统计学意义（P〈0.01）。结论双侧原发性乳腺癌第二癌与第一癌可视为两个完全不同的癌灶。单侧发生乳癌之后对侧乳癌发生的累积危险度逐年增加,应建立完善的随访制度。异时性双乳癌的5年无病生存率与10年总生存率均高于同时性双乳癌。 |
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| AbstractList | 目的探讨原发性双侧乳腺癌（bilateral primary breast cancer,BPBC）患者的临床病理特征。方法收集1971年1月—2011年11月间我院诊治的565例双乳癌患者临床资料。对比分析同时性双乳癌（bilateral synchronous breast cancer）和异时性双乳癌（bilateral asynchronous breast cancer）在发病年龄、发病间隔、月经情况、家族史、肿瘤体积、临床分期、淋巴结数目、激素受体等临床病理特征的差异。结果异时性双乳癌首发癌年龄要早于同时性双乳癌（P〈0.05）。同时性/异时性双乳癌在家族史、肿瘤体积、临床分期、腋淋巴结数目方面的差异均无统计学意义（P〉0.05）。同时性双乳癌两侧病灶内分泌受体表达一致率高于异时性双乳癌（P〈0.01）。无论同时性或异时性双乳癌其第二癌的肿瘤体积、临床分期和腋淋巴结情况都优于第一癌。同时性双乳癌与异时性双乳癌5年无病生存率与10年总生存率之间的差异有统计学意义（P〈0.01）。结论双侧原发性乳腺癌第二癌与第一癌可视为两个完全不同的癌灶。单侧发生乳癌之后对侧乳癌发生的累积危险度逐年增加,应建立完善的随访制度。异时性双乳癌的5年无病生存率与10年总生存率均高于同时性双乳癌。 |
| Author | 张晟 张霄蓓 郝晓甍 张瑾 |
| AuthorAffiliation | 天津医科大学附属肿瘤医院天津乳腺癌防治研究中心乳腺三科,教育部乳腺癌防治重点实验室,天津市肿瘤防治重点实验室,天津300060 |
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| DocumentTitleAlternate | Analysis of Clinical and Pathological Features of 565 Cases of Bilateral Primary Breast Cancer |
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| Notes | 42-1241/R Bilateral primary breast cancer; Bilateral synchronous breast cancer; Bilateral asynchronous breast cancer Objective To investigate the clinical and pathological features of primary bilateral breast cancer（BPBC）.Methods Medical records of BPBC patients were reviewed from the Tianjin Medical University Cancer Institute and Hospital during 1.1971—11.2011 Data of the synchronous and asynchronous breast cancer were analyzed,including the age of tumor onset,the time interval between two cancer,menstruation,family history,the size of tumor,clinical stage,pathologic characteristics.Results First cancer onset age of the asynchronous breast cancer was earlier than that of synchronous breast cancer（P0.05）.There were no statistical difference between synchronous and asynchronous breast cancer on family history,the size of tumor,clinical stage and pathologic characteristics（P0.05）.The concordance rate of endocrine receptors in synchronous was higher than that in asynchronous breast cancer（P0.01）.Clinical stage,tu |
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| PublicationTitle | 肿瘤防治研究 |
| PublicationTitleAlternate | Cancer Research on Prevention and Treatment |
| PublicationYear | 2012 |
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| Snippet | 目的探讨原发性双侧乳腺癌（bilateral primary breast cancer,BPBC）患者的临床病理特征。方法收集1971年1月—2011年11月间我院诊治的565例双乳癌患者临床资料。对比分析同时性双乳癌（bilateral synchronous breast... |
| SourceID | chongqing |
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| StartPage | 632 |
| SubjectTerms | 原发性双乳癌 同时性双乳癌 异时性双乳癌 |
| Title | 565例双侧原发性乳腺癌临床病理特征分析 |
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