不同反应体系中（S）-1-（4-甲氧基）-苯基乙醇的不对称生物合成

在不同反应体系中,研究了固定化红酵母细胞催化对甲氧基苯乙酮不对称还原合成（S）-1-（4-甲氧基）-苯基乙醇的反应.结果表明,在含离子液体的混合反应体系和双相反应体系中,该不对称还原反应的效率得到了不同程度的提高.此外,离子液体中阴阳离子类型对该反应的影响较大,特定阴阳离子间的匹配对固定化红酵母细胞发挥最佳催化效果至关重要....

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Bibliographic Details
Published in催化学报 Vol. 32; no. 6; pp. 1003 - 1010
Main Author 汪薇 宗敏华 娄文勇
Format Journal Article
LanguageChinese
Published 2011
Subjects
1-（4-甲氧基）-苯基乙醇
不对称生物合成
催化
对甲氧基苯乙酮
微生物细胞
离子液体
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Summary:在不同反应体系中,研究了固定化红酵母细胞催化对甲氧基苯乙酮不对称还原合成（S）-1-（4-甲氧基）-苯基乙醇的反应.结果表明,在含离子液体的混合反应体系和双相反应体系中,该不对称还原反应的效率得到了不同程度的提高.此外,离子液体中阴阳离子类型对该反应的影响较大,特定阴阳离子间的匹配对固定化红酵母细胞发挥最佳催化效果至关重要.
Bibliography:WANG Wei1,ZONG Minhua2,＊,LOU Wenyong2 1College of Light Industry and Food Science,ZhongKai University of Agriculture and Engineering,Guangzhou 510225,Guangdong,China 2Laboratory of Applied Biocatalysis,South China University of Technology,Guangzhou 510640,Guangdong,China
4-methoxyacetophenone; 1-（4-methoxyphenyl）ethanol; ionic liquid; catalysis; microbial cell; asymmetric biosynthesis
21-1195/O6
The biocatalytic enantioselective reduction of 4-methoxyacetophenone to （S）-1-（4-methoxyphenyl）ethanol was studied.The efficiency of the reaction was improved to different extents when an ionic liquid-containing co-solvent system and an ionic liquids/bufffer biphasic system were used.The catalytic performance of the biocatalyst depended not only on the types of the anions and cations in the ionic liquids but also on their combination.
ISSN:0253-9837
1872-2067