荧光原位杂交在子宫颈病变的癌变风险预测中的应用
目的探讨hTERC基因在不同宫颈病变中的扩增情况及hTERC基因扩增对宫颈病变发展趋势的预测意义。方法利用FISH在荧光显微镜下观察3号染色体着丝粒CSP3和hTERC基因双色探针的杂交效果,检测不同宫颈病变中hTERC基因扩增情况,对部分存在hTERC基因扩增的患者进行随访。结果随着宫颈病变的发展,hTERC基因扩增的阳性率及扩增的细胞所占比例均在不断升高,差异具有统计学意义。结论 hTERC基因扩增与宫颈病变的发展密切相关,FISH检测hTERC基因是否存在扩增可能成为预测宫颈病变发展趋势的可靠手段。...
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| Published in | Zhongliu fangzhi yanjiu Vol. 38; no. 4; pp. 420 - 422 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
2011
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-8578 |
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| Abstract | 目的探讨hTERC基因在不同宫颈病变中的扩增情况及hTERC基因扩增对宫颈病变发展趋势的预测意义。方法利用FISH在荧光显微镜下观察3号染色体着丝粒CSP3和hTERC基因双色探针的杂交效果,检测不同宫颈病变中hTERC基因扩增情况,对部分存在hTERC基因扩增的患者进行随访。结果随着宫颈病变的发展,hTERC基因扩增的阳性率及扩增的细胞所占比例均在不断升高,差异具有统计学意义。结论 hTERC基因扩增与宫颈病变的发展密切相关,FISH检测hTERC基因是否存在扩增可能成为预测宫颈病变发展趋势的可靠手段。 |
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| AbstractList | 目的探讨hTERC基因在不同宫颈病变中的扩增情况及hTERC基因扩增对宫颈病变发展趋势的预测意义。方法利用FISH在荧光显微镜下观察3号染色体着丝粒CSP3和hTERC基因双色探针的杂交效果,检测不同宫颈病变中hTERC基因扩增情况,对部分存在hTERC基因扩增的患者进行随访。结果随着宫颈病变的发展,hTERC基因扩增的阳性率及扩增的细胞所占比例均在不断升高,差异具有统计学意义。结论 hTERC基因扩增与宫颈病变的发展密切相关,FISH检测hTERC基因是否存在扩增可能成为预测宫颈病变发展趋势的可靠手段。 |
| Author | 杨继洲 肖兰 杨娟 |
| AuthorAffiliation | 孝感市中心医院病理科,湖北孝感432000 孝感市中心医院妇产科,湖北孝感432000 |
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| Notes | Fluorescence in situ hybridisation; Cervical intraepithelial neoplasia; hTERC gene 42-1241/R Fluorescence in situ hybridisation R737.33 Cervical intraepithelial neoplasia hTERC gene |
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| SubjectTerms | hTERC基因 宫颈上皮内病变 荧光原位杂交 |
| Title | 荧光原位杂交在子宫颈病变的癌变风险预测中的应用 |
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