HBeAg与原发性肝癌和病毒相关因素的分析

目的研究HBeAg阴性与HBeAg阳性的原发性肝癌患者临床特点和病毒相关因素的差异,并探讨其临床意义。方法对1028例原发性肝癌患者的住院病历进行回顾性调查,将患者分为HBeAg阳性组和阴性组。分析两组门脉癌栓、AFP水平、HBV DNA定量、Child-Paugh分级及肝组织病理学指标的差异。结果 HBeAg阴性原发性肝癌895例,占总数的87.1%;HBeAg阳性原发性肝癌133例,占总数的12.9%;HBeAg阳性组合并门脉癌栓的比例为18.6%,显著高于HBeAg阴性组的11.8%（χ2=4.46,P=0.035）。HBeAg阳性组HBV DNA定量对数均值显著高于HBeAg阴性组（χ...

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Published inZhongliu fangzhi yanjiu Vol. 37; no. 12; pp. 1391 - 1393
Main Author 于静 刘博伟 袁媛 兰玲 张昊 贾长河
Format Journal Article
LanguageChinese
Published 2010
Subjects
Child-Paugh分级
DNA
HBV
乙肝病毒e抗原
原发性肝癌
组织学
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Abstract 目的研究HBeAg阴性与HBeAg阳性的原发性肝癌患者临床特点和病毒相关因素的差异,并探讨其临床意义。方法对1028例原发性肝癌患者的住院病历进行回顾性调查,将患者分为HBeAg阳性组和阴性组。分析两组门脉癌栓、AFP水平、HBV DNA定量、Child-Paugh分级及肝组织病理学指标的差异。结果 HBeAg阴性原发性肝癌895例,占总数的87.1%;HBeAg阳性原发性肝癌133例,占总数的12.9%;HBeAg阳性组合并门脉癌栓的比例为18.6%,显著高于HBeAg阴性组的11.8%（χ2=4.46,P=0.035）。HBeAg阳性组HBV DNA定量对数均值显著高于HBeAg阴性组（χ2=12.81,P=0.00）;HBeAg阳性组Child-Paugh分级为B级和C级的分别为18.3%和15.0%,明显高于HBeAg阴性组的12.9%和1.0%;HBeAg阳性组肝纤维化分期为4期的比例为35.5%,明显高于HBeAg阴性组的24.5%（χ2=4.98,P=0.026）。两组在AFP等指标上无统计学差异。结论同HBeAg阴性原发性肝癌相比,HBeAg阳性肝癌患者肝组织学损害程度较重,合并门脉癌栓、肝硬化更为常见,预后更差。
AbstractList 目的研究HBeAg阴性与HBeAg阳性的原发性肝癌患者临床特点和病毒相关因素的差异,并探讨其临床意义。方法对1028例原发性肝癌患者的住院病历进行回顾性调查,将患者分为HBeAg阳性组和阴性组。分析两组门脉癌栓、AFP水平、HBV DNA定量、Child-Paugh分级及肝组织病理学指标的差异。结果 HBeAg阴性原发性肝癌895例,占总数的87.1%;HBeAg阳性原发性肝癌133例,占总数的12.9%;HBeAg阳性组合并门脉癌栓的比例为18.6%,显著高于HBeAg阴性组的11.8%（χ2=4.46,P=0.035）。HBeAg阳性组HBV DNA定量对数均值显著高于HBeAg阴性组（χ2=12.81,P=0.00）;HBeAg阳性组Child-Paugh分级为B级和C级的分别为18.3%和15.0%,明显高于HBeAg阴性组的12.9%和1.0%;HBeAg阳性组肝纤维化分期为4期的比例为35.5%,明显高于HBeAg阴性组的24.5%（χ2=4.98,P=0.026）。两组在AFP等指标上无统计学差异。结论同HBeAg阴性原发性肝癌相比,HBeAg阳性肝癌患者肝组织学损害程度较重,合并门脉癌栓、肝硬化更为常见,预后更差。
Author 于静 刘博伟 袁媛 兰玲 张昊 贾长河
AuthorAffiliation 河南省人民医院二内消化科,郑州450003
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Hepatitis B e antigens
Primary hepatic cancer; Hepatitis B e antigens; HBV DNA; Child-Paugh Grading; Histology
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HBV DNA
Child-Paugh Grading
Histology
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Snippet 目的研究HBeAg阴性与HBeAg阳性的原发性肝癌患者临床特点和病毒相关因素的差异,并探讨其临床意义。方法对1028例原发性肝癌患者的住院病历进行回顾性调查,将患者分为HBeAg阳性组和阴性组。分析两组门脉癌栓、AFP水平、HBV DNA定量、Child-Paugh分级及肝组织病理学指标的差异。结果...
SourceID chongqing
SourceType Publisher
StartPage 1391
SubjectTerms Child-Paugh分级
DNA
HBV
乙肝病毒e抗原
原发性肝癌
组织学
Title HBeAg与原发性肝癌和病毒相关因素的分析
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