Antifibrotic effects of ZK14, a novel nitric oxidedonating biphenyldicarboxylate derivative, on rat HSC-T6 cells and CCI4-induced hepatic fibrosis

• Published in: Acta pharmacologica Sinica no. 1; pp. 27 - 34
• Main Author: Li DAI Hui JI Xiang-wen KONG Yi-hua ZHANG
• Format: Journal Article
• Language: English
• Published: 2010
• Subjects: HSC; 四氯化碳; 联苯双酯; 肝纤维化; 衍生物

Aim： To study the pharmacologic effect of ZK14, a novel nitric oxide-donating biphenyldicarboxylate （DDB） derivative, on HSC-T6 cells and on CCI4-induced hepatic fibrosis. Methods： Inhibition of HSC-T6 cell growth by ZK14 was evaluated by MTT assay. The effect of ZK14 on the percentage of HSC-T6 cel...