Understanding the adhesome network in primary and metastatic cutaneous squamous cell carcinoma

• Main Author: Li Mow Chee, Frederic Paul Li Kwet Khiong
• Format: Dissertation
• Language: English
• Published: University of Edinburgh 2019
• Subjects: cutaneous squamous cell; DNA methylation; EMERIN; extracellular matrix; Mena; metastasis; SCC

Understanding how cancer cells survive, invade and migrate is of fundamental importance to the development of approaches to inhibit invasion and metastasis in patients. Proteins recruited at adhesion complexes, known as the adhesome, are involved in multiple mechanisms which control cancer cell beha...