Indirect analysis of oligonucleotides using cleavable small molecule mass tags with detection by mass spectrometry

• Main Author: Riley, Jo-Anne
• Format: Dissertation
• Language: English
• Published: University of Southampton 2013
• Subjects: QD Chemistry

In the 1990s, siRNAs and microRNAs were discovered to be naturally occurring genetic regulators. This provided a new potential mechanism of action for drugs with applicability to a wide range of therapeutic areas. Consequently, a substantial increase into oligonucleotide research has occurred, leadi...