Study of Wolfram Syndrome in neuronal cell models

• Main Author: Gharanei, Seley
• Format: Dissertation
• Language: English
• Published: University of Birmingham 2013
• Subjects: R Medicine (General)

Wolfram Syndrome (WS) is a rare autosomal recessive disease characterised by insulin-dependent diabetes mellitus, optic nerve atrophy. The current study demonstrated that neuronal cells depleted of WFS1 protein, showed significantly elevated expression of the ER stress markers indicating an enhanced...