Hetero Diels−Alder-Biocatalysis Approach for the Synthesis of (S)-3-[2-{(Methylsulfonyl) oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol Methanesulfonate, a Key Intermediate for the Synthesis of the PKC Inhibitor LY3335311

• Published in: Organic process research & development Vol. 6; no. 4; pp. 471 - 476
• Main Authors: Caille, Jean-Claude, Govindan, C. K, Junga, Heiko, Lalonde, Jim, Yao, Yiming
• Format: Journal Article
• Language: English
• Published: American Chemical Society 19.07.2002

A cost-effective and easily scaled-up process has been developed for the synthesis of (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methanesulfonate, a key intermediate used in the synthesis of a protein kinase C inhibitor drug through a combination of hetero Diels−Alder and b...