Novel mechanism underlying the APOE ε2 protective effect for Alzheimer disease implicated by integrative genome and transcriptome analysis

• Published in: Alzheimer's & dementia Vol. 16
• Main Authors: Panitch, Rebecca, Zhu, Congcong, Hu, Junming, Chung, Jaeyoon, Stein, Thor D., Farrer, Lindsay A., Jun, Gyungah R.
• Format: Journal Article
• Language: English
• Published: 01.12.2020

Background The APOE ε4 allele is the strongest genetic risk factor for late onset Alzheimer disease (AD) and the ε2 allele is known to mitigate risk of AD. While potential mechanisms accounting for AD risk associated with ε4 have been extensively studied, the mechanism underlying the protective effe...