A spectrophotometric method for the determination of prazosin hydrochloride in tablets

A rapid and sensitive analytical method was developed for the spectrophotometric assay of prazosin hydrochloride. The method is based on the formation of a coloured derivative between the drug and 1,2-naphthoquinone-4- sulphonic acid sodium salt (NQS). The reaction proceeds quantitatively at pH 4.5...

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Bibliographic Details
Published inTurkish journal of chemistry Vol. 26; no. 5; pp. 691 - 696
Main Authors ÖZGÜR, Mahmure,Üstün, SUNGUR, Sıdıka
Format Journal Article
LanguageEnglish
Published TÜBİTAK 2002
Subjects
1,2-naftokinon-4-sülfonik asit sodyum tuzu
1,2-naphthoquinone-4-sulfonic acid sodium salt
Absorbance
Abzorbans
Analitik Kimya, Ayırma Yöntemleri
Analytical Chemistry, Separation Methods
Diferansiyel vurulu polarografi
differential pulse polarography
Eczacılık
F-test
Fizikokimya
Fizikokimyasal Eczacılık
Pharmacy in General
Physical Chemistry
Physicochemical Pharmacy
Prazosin hidroklorür
Prazosin hydrochloride
spectrophotometry[analysis]
Spektrofotometri[analiz]
Tablet[farmasötikler]
tablet[pharmaceuticals]
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Summary:A rapid and sensitive analytical method was developed for the spectrophotometric assay of prazosin hydrochloride. The method is based on the formation of a coloured derivative between the drug and 1,2-naphthoquinone-4- sulphonic acid sodium salt (NQS). The reaction proceeds quantitatively at pH 4.5 and 70°C for 40 min. After the extraction of the derivative with chloroform: n-butanol (3:1), the absorbance was measured at 400 nm. The method was applied to commercially available tablets and the results were statistically compared with those obtained by ultraviolet spectrophotometric and differential pulse polarographic methods using t- and F-tests.
Bibliography:TMUH
ISSN:1300-0527
1303-6130