Activation of the CRF1 receptor causes ERK1/2 mediated increase in GRK3 expression in CATH.a cells

• Published in: FEBS letters Vol. 581; no. 17; pp. 3204 - 3210
• Main Authors: Salim, Samina, Hite, Brian, Eikenburg, Douglas C.
• Format: Journal Article
• Language: English
• Published: 10.07.2007
• Subjects: adrenoceptor; Bipolar disorder; EPI; epinephrine; ERK; extracellular signal-regulated kinase; G-protein coupled receptor kinases; G-protein coupled receptors; GPCRs; GRK; Kinase; MAPK; MAPK/ERK kinase; MEK; mitogen-activated protein kinase; Nucleus; polyvinylidene difluoride; Protein synthesis; PVDF; reverse transcriptase polymerase chain reaction; RT-PCR; Stress; Transcription

G‐protein coupled receptor kinase 3 (GRK3) mediates desensitization of alpha2‐adrenergic (α2‐AR) and CRF1 receptors. CRF1 receptors, α2‐AR and GRK3, are localized to the primary source of noradrenergic inputs to higher brain centers critical in both the response to stress and the development of depr...