Diastereoselective Construction of CF3‐Containing Bispiro[isoquinolone‐pyrrolidine‐benzothiophenone]s through 1,3‐Dipolar Cycloaddition

• Published in: European journal of organic chemistry Vol. 2022; no. 26
• Main Authors: Niu, Cheng, Du, Da‐Ming
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 14.07.2022
• Subjects: 1,3-Dipolar cycloaddition; Asymmetric catalysis; Benzothiophenones; Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; Synthetic methods; Trifluoroethyl ketimines; 1; Benzothiophenones; ENANTIOSELECTIVE SYNTHESIS; 3-Dipolar cycloaddition; Trifluoroethyl ketimines; Synthetic methods; Asymmetric catalysis; DERIVATIVES; SPIROOXINDOLES

A new protocol to access CF3‐containing bispiro[isoquinolone‐pyrrolidine‐benzothiophenone]s was described. A series of 1,3‐dipoles were synthesized from isoquinolinetrione and CF3CH2NH2. In the presence of 10 mol% DABCO, the 1,3‐dipolar cycloaddition of isoquinolinedione trifluoroethyl ketimines and...