Anticancer effects of nanometallic oxides and their ligands with photosensitizers in osteosarcoma cells

• Published in: Journal of Optoelectronics and Advanced Materials Vol. 17; no. 11-12; p. 1808
• Main Authors: Fakhar-E-Alam, M., Kishwer, Sultana, Abbas, Najeeb, Atif, M., Nour, Omer, Willander, Magnus, Amin, Nasir, Farooq, W. A.
• Format: Journal Article
• Language: English
• Published: 01.11.2015
• Subjects: Osteosarcoma cell; reactive oxygen species (ROS); photodynamic therapy (PDT); MTT assay
• ISSN: 1454-4164; 1841-7132

We studied the cytotoxic effects in Osteosarcoma (U2OS) cells to different nanosized metallic oxides e.g. zinc oxide nanowires (ZnO-NRs), manganese di-oxide nanowires (MnO2 NWs), ferric oxide nanoparticles (Fe2O3 NPs) individually and their connplexed forms with photosensitizers photofrin (R), 5-Aminolevulinic acid (5-ALA), and protoporphyrin IX (Pp IX). Cellular toxicity was assayed by cellular morphology, reactive oxygen species (ROS) detection, MTT assay under ultraviolet (UV), visible light and laser exposed conditions. Prominent cell death with above cited nanomaterials in their complexed forms with Photosensitizer was observed in labeled U2OS cells. This cell death might be due to their synergetic effect via the release of singlet oxygen species in Osteosarcoma cells showing their anticancer-cell effects.