Regio- and stereoselective α-halogenation of 2-aryl-1-methylsulfonyl-2,3-dihydroquinolin-4(1H)-ones

• Published in: South African journal of chemistry Vol. 54; no. 1; pp. 60 - 68
• Main Authors: Hlatshwayo, S.M., Fernandes, M.A., Mphahlele, M.J., Ndlovu, S.M.
• Format: Journal Article
• Language: English
• Published: South African Chemical Institute (SACI) 21.05.2001
• Subjects: Halogenation; Quinolones; Reseach articles; Stereochemistry; X-ray crystallography

2-Aryl-1-methylsulfonyl-2,3-dihydroquinolin-4(1H)-ones are readily converted into the corresponding 2-aryl-3-iodo- and 2-aryl-3-bromo-1-methylsulfonyl-2,3-dihydroquinolin-4(1H)-ones using iodine in methanol and pyridinium perbromide in acetic acid, respectively. The reactions were found to be regios...