Glutamine Synthetase Stability and Subcellular Distribution in Astrocytes are Regulated by G-Aminobutyric Type B Receptors

• Published in: The Journal of biological chemistry Vol. 289; no. 42; p. 28808
• Main Authors: Huyghe, Deborah, Nakamura, Yasuko, Terunuma, Miho, Faideau, Mathilde, Haydon, Philip, Pangalos, N Mene, Stephen, Moss J
• Format: Journal Article
• Language: English
• Published: 2014
• Subjects: Basic Medicine; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Neurosciences; Neurovetenskaper

Emerging evidence suggests that functional γ-aminobutyric acid B receptors (GABABRs) are expressed by astrocytes within the mammalian brain. GABABRs are heterodimeric G-protein coupled receptors that are composed of R1/R2 subunits. To date, they have been characterized in neurons as the principal me...