Significado do epitope spreading na patogênese dos pênfigos vulgar e foliáceo

Os pênfigos são dermatoses bolhosas auto-imunes, em que há a produção de auto-anticorpos direcionados contra moléculas de adesão dos epitélios, levando à perda da coesão celular. A produção de auto-anticorpos ocorre quando os pacientes desenvolvem um desequilíbrio da resposta imune (quebra da tolerâ...

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Published inAnais brasileiros de dermatología Vol. 83; no. 2; pp. 157 - 161
Main Authors Aoki, Valéria, Lago, Fernanda, Yamazaki, Márcia Harumi, Santi, Cláudia Giuli, Maruta, Celina Wakisaka
Format Journal Article
LanguagePortuguese
Published Sociedade Brasileira de Dermatologia 01.04.2008
Subjects
DERMATOLOGY
Autoimmunity
Pênfigo
Auto-imunidade
Pemphigus
Desmogleínas
Epítopos
Epitopes
Desmogleins
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Abstract Os pênfigos são dermatoses bolhosas auto-imunes, em que há a produção de auto-anticorpos direcionados contra moléculas de adesão dos epitélios, levando à perda da coesão celular. A produção de auto-anticorpos ocorre quando os pacientes desenvolvem um desequilíbrio da resposta imune (quebra da tolerância imunológica), passando a reconhecer antígenos próprios. A resposta é geralmente direcionada contra um único epítopo alvo; entretanto, como conseqüência da resposta inflamatória do processo primário e do extenso dano tecidual ocasionado, pode haver exposição de componentes protéicos ocultos, levando à produção de diferentes auto-anticorpos. Assim, é possível que surja uma nova doença cutânea auto-imune, em decorrência do fenômeno intra ou intermolecular de epitope spreading. São revistos os principais conceitos desse fenômeno e sua ocorrência nas dermatoses bolhosas auto-imunes, com ênfase nos pênfigos, grupo de dermatoses bolhosas autoimunes mais prevalente no Brasil.
AbstractList Os pênfigos são dermatoses bolhosas auto-imunes, em que há a produção de auto-anticorpos direcionados contra moléculas de adesão dos epitélios, levando à perda da coesão celular. A produção de auto-anticorpos ocorre quando os pacientes desenvolvem um desequilíbrio da resposta imune (quebra da tolerância imunológica), passando a reconhecer antígenos próprios. A resposta é geralmente direcionada contra um único epítopo alvo; entretanto, como conseqüência da resposta inflamatória do processo primário e do extenso dano tecidual ocasionado, pode haver exposição de componentes protéicos ocultos, levando à produção de diferentes auto-anticorpos. Assim, é possível que surja uma nova doença cutânea auto-imune, em decorrência do fenômeno intra ou intermolecular de epitope spreading. São revistos os principais conceitos desse fenômeno e sua ocorrência nas dermatoses bolhosas auto-imunes, com ênfase nos pênfigos, grupo de dermatoses bolhosas autoimunes mais prevalente no Brasil.
Author Maruta, Celina Wakisaka
Yamazaki, Márcia Harumi
Aoki, Valéria
Lago, Fernanda
Santi, Cláudia Giuli
AuthorAffiliation Universidade de São Paulo
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  givenname: Celina Wakisaka
  surname: Maruta
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  organization: Universidade de São Paulo
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DocumentTitleAlternate Significance of epitope spreading in the pathogenesis of pemphigus vulgaris and foliaceus
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Issue 2
Keywords Autoimmunity
Pênfigo
Auto-imunidade
Pemphigus
Desmogleínas
Epítopos
Epitopes
Desmogleins
Language Portuguese
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Snippet Os pênfigos são dermatoses bolhosas auto-imunes, em que há a produção de auto-anticorpos direcionados contra moléculas de adesão dos epitélios, levando à perda...
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Title Significado do epitope spreading na patogênese dos pênfigos vulgar e foliáceo
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