Synthesis of impurity A in Carvedilol: a beta-adrenergic receptor

Carvedilol is prepared by different synthetic approaches. Almost in all the approaches the major impurities that are known in the literature A, B, C, D and E are listed in European pharmacopoeia. The control of pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. I...

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Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 48; no. 5; pp. 741 - 745
Main Authors Madhusudhan, G., Naidu, K. Chinnam, Kumar, B. Anand, Satyanarayana, R., Balraju, V.
Format Journal Article
LanguageEnglish
Published NEW DELHI COUNCIL SCIENTIFIC & INDUSTRIAL RES 01.05.2009
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
beta-adrenergic receptor
CHRONIC HEART-FAILURE
OXIDATIVE STRESS
POTENT
SERIES
Carvedilol
impurities
METOPROLOL
ADRENOCEPTOR ANTAGONIST
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Summary:Carvedilol is prepared by different synthetic approaches. Almost in all the approaches the major impurities that are known in the literature A, B, C, D and E are listed in European pharmacopoeia. The control of pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this publication.. a description of these impurities and their origins in Carvedilol process are presented along with the preparation of impurity A.
ISSN:0376-4699