A simple and convenient synthetic method for alpha-trifluoromethylpyridines

• Published in: Heterocycles Vol. 46; pp. 129 - 132
• Main Authors: Okada, E, Kinomura, T, Higashiyama, Y, Takeuchi, H, Hojo, M
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 31.12.1997
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; S-N; SULFIDES; SUBSTITUTIONS; OLEFINIC CARBON-ATOMS; CHEMISTRY; N EXCHANGE-REACTIONS; DIHYDROPYRIDINES; FACILE

beta-Trifluoroacetylvinylamine (1) reacted easily with various active methylene compounds in the presence of trifluoroacetic acid under mild conditions to give alpha-trifluoromethylpyridines (2) in moderate to high yields.