Synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

1,3-Dihydro-2N-indol-3-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (5) and its derivatives, and the appli...

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Bibliographic Details
Published inTetrahedron letters Vol. 42; no. 6; pp. 999 - 1001
Main Authors Cheung, M, Harris, PA, Lackey, KE
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 05.02.2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HETEROAROMATIC RING-SYSTEMS
KINASE
INHIBITORS
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Summary:1,3-Dihydro-2N-indol-3-ones (oxindoles) and 1,3-dihydro-2H-pyrrolopyridin-2-ones (azaoxindoles) are useful scaffolds that have been explored for various pharmaceutical uses. Herein we report the synthesis of 2-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (5) and its derivatives, and the application of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones (diazaoxindoles) as novel scaffold to kinase research areas. (C) 2001 Elsevier Science Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/S0040-4039(00)02219-X