Toxic Activation of an AAA plus Protease by the Antibacterial Drug Cyclomarin A

• Published in: Cell chemical biology Vol. 26; no. 8; p. 1169
• Main Authors: Maurer, Michael, Linder, Daniela, Franke, Kamila B., Jäger, Jasmin, Taylor, Gabrielle, Gloge, Felix, Gremer, Sebastian, Le Breton, Laura, Mayer, Matthias P., Weber-Ban, Eilika, Carroni, Marta, Bukau, Bernd, Mogk, Axel
• Format: Journal Article
• Language: English
• Published: 15.08.2019

ATP-driven bacterial AAA+ proteases have been recognized as drug targets. They possess an AAA+ protein (e.g., ClpC), which threads substrate proteins into an associated peptidase (e.g., ClpP). ATPase activity and substrate selection of AAA+ proteins are regulated by adapter proteins that bind to reg...