Renin-Angiotensin Aldosterone System Inhipitors and COVID-19 A Systematic Review and Meta-Analysis Revealing Critical Bias Across a Body of Observational Research

• Published in: Journal of the American Heart Association Vol. 11; no. 11
• Main Authors: Loader, Jordan, Taylor, Frances C., Lampa, Erik, Sundström, Johan
• Format: Journal Article
• Language: English
• Published: 07.06.2022
• Subjects: angiotensin receptor blockers; angiotensin-converting enzyme inhibitors; calcium channel blockers; COVID-19; reninaldosterone angiotensin system inhibitors; thiazide diuretics

BACKGROUND: Renin-angiotensin aldosterone system (RAAS) inhibitor-COVID-19 studies, observational in design, appear to use biased methods that can distort the interaction between RAAS inhibitor use and COVID-19 risk. This study assessed the extent of bias in that research and reevaluated RAAS inhibi...