Many αIIbβ3 autoepitopes in chronic immune thrombocytopenic purpura are localized to αIIb between amino acids L1 and Q459

• Published in: British journal of haematology Vol. 118; no. 4; pp. 1132 - 1136
• Main Authors: Mcmillan, Robert, Wang, Lei, Lopez‐Dee, Jennifer, Jiu, Sandra, Loftus, Joseph C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.2002
• Subjects: antiplatelet antibody; autoantibody; autoimmune; chronic ITP

In chronic immune thrombocytopenic purpura (ITP), autoantibodies bind to platelet surface proteins, particularly αIIb, resulting in platelet destruction by the reticulo‐endothelial system. In order to better localize the autoepitopes on αIIb, we studied the binding of antibodies to Chinese hamster o...