Cysteine Cathepsins and Cystatins as Cancer Biomarkers

• Published in: The Cancer Degradome pp. 587 - 625
• Main Authors: Lah, Tamara T., Obermajer, Nataša, Alonso, María Beatriz Durán, Kos, Janko
• Format: Book Chapter
• Language: English
• Published: New York, NY Springer New York 2008
• Subjects: Benign Meningioma; Breast Cancer; Cysteine Cathepsin; Prostate Carcinoma; Tongue Cancer

Cysteine cathepsins are lysosomal cysteine proteases that are involved in a number of important biological processes, including intracellular protein turnover, propeptide and prohormone processing, apoptosis, bone remodelling, and reproduction. In cancer, the cathepsins have been linked to extracell...