Absolute quantification of Cohesin, CTCF and their regulators in human cells

• Published in: eLife Vol. 8
• Main Authors: Holzmann, Johann, Politi, Antonio Z., Nagasaka, Kota, Hantsche-Grininger, Merle, Walther, Nike, Koch, Birgit, Fuchs, Johannes, Dürnberger, Gerhard, Tang, Wen, Ladurner, Rene, Stocsits, Roman R., Busslinger, Georg A., Novák, Béla, Mechtler, Karl, Davidson, Iain Finley, Ellenberg, Jan, Peters, Jan Michael
• Format: Journal Article
• Language: English
• Published: 01.06.2019
• Subjects: Cell and Molecular Biology; Cell- och molekylärbiologi

The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating cells, cohesin also mediates sister chromatid cohesi...